抗苗勒管激素与年龄的关系及其预测卵巢衰老的临床研究  

Clinical study of anti-Mullerian hormone in prediction of ovarian aging

作　　者：高丽虹[1] 蔡文伟[1] 朱琴[1] 李永祥[1] 金倩燕 张梅光[2] 蔡英如 周芝婷 吴晓杰[2] 

机构地区：[1]浙江省嘉兴市妇幼保健院妇产科,314000 [2]嘉兴学院妇产科系

出　　处：《中华妇产科杂志》2015年第5期352-355,共4页Chinese Journal of Obstetrics and Gynecology

基　　金：浙江省嘉兴市科技计划（2013AY21050-7）

摘　　要：目的：研究不同年龄阶段月经正常的生育期妇女抗苗勒管激素（AMH）水平的变化，了解AMH与年龄的关系及其在预测卵巢衰老中的价值。方法选择2012年12月至2014年7月在嘉兴市妇幼保健院行健康体检的月经正常的1423例生育期妇女，按年龄阶段分为：≤25岁、26～30岁、31～35岁、36～40岁、≥41岁，检测其血清AMH水平，并分析与年龄的关系。结果≤25岁、26～30岁、31～35岁、36～40岁、≥41岁妇女的血清AMH水平中位数分别为3.62、3.10、2.27、1.07、0.45μg/L；不同年龄阶段妇女血清AMH水平比较，差异有统计学意义（H=232.386，P〈0.01）。血清AMH水平与年龄呈负相关（r=－0.374，P〈0.01）；血清AMH水平在25岁后即开始下降，36岁后下降明显。logAMH （即AMH的对数）的二次回归拟合最佳地反映了AMH与年龄的关系。结论检测生育期妇女血清AMH水平可早期预示卵巢功能的下降，可作为预警卵巢衰老的指标。Objective To explore the serum anti-Mullerian hormone （AMH） level in women of childbearing age with normal menstrual cycles. Methods A total of 1 423 women with regular menstrual cycles were selected and divided into 5 groups according to their ages, i.e.≤25, 26-30, 31-35, 36-40,≥41 years. Their serum levels of AMH were measured, and the relationship between AMH and age was analyzed. Results The serum AMH levels of 5 groups according to ages （≤25, 26-30, 31-35, 36-40, ≥41 years） were 3.62, 3.10, 2.27, 1.07, 0.45μg/L, respectively. The comparison of serum AMH levels in different age groups had significant difference （P〈0.01）. Serum AMH level declined with increasing age,and dropped significantly after 36. The serum AMH level and age showed a negative correlation with significant difference （r=-0.374, P〈0.01）. Quadratic regression of logAMH proximally reflected the relationship between AMH and age. Conclusion AMH determination for women of childbearing age could provide reference for the evaluation of ovarian function.

关 键 词：卵巢 抗苗勒管激素 年龄因素 细胞衰老 

分 类 号：R711.75[医药卫生—妇产科学]