以高胰岛素-正葡萄糖钳夹技术评估成人1型糖尿病患者的胰岛素敏感性  

Evaluation of insulin sensitivity by hyperinsulinemic-euglycemic clamp technique in Chinese patients with type 1 diabetes mellitus

作　　者：黄滨[1] 翁建平[1] 杨黛稚[1] 艾鹤英[1] 吕婧[1] 章燕[1] 郑雪瑛[1] 刘莉[1] 严晋华[1] 姚斌[1] 

机构地区：[1]中山大学附属第三医院内分泌与代谢病学科广东省糖尿病防治重点实验室,广州510630

出　　处：《中华糖尿病杂志》2015年第5期302-305,共4页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：国家自然科学基金（81100556）;中山大学临床医学研究5010计划项目（2007030）

摘　　要：目的：通过高胰岛素-正葡萄糖钳夹技术来精确评估成人1型糖尿病（T1DM）患者的胰岛素敏感性。方法2011年6月至2013年6月招募在中山大学附属第三医院随访的10例成年T1DM患者和10例正常葡萄糖耐量（NGT）的志愿者，2组男女各半，年龄分别为（27±57）岁、（27±8）岁。体质指数、腰围相匹配。分别对其实施高胰岛素-正葡萄糖钳夹试验，计算稳态期的葡萄糖处置率以了解受试者的胰岛素敏感性。组间差异比较采用t检验。结果 T1DM组的糖化血红蛋白高于NGT组[（7.5±0.8）%比（5.2±0.3）%，t=-6.318，P0.05）。T1DM组和NGT组的葡萄糖处置率分别为（7.8±1.9）mg·kg-1· min-1和（14.0±1.7）mg·kg-1·min-1，差异有统计学意义（t=7.769，P〈0.001）。结论成人T1DM患者可能存在一定程度的胰岛素抵抗。Objective To investigate insulin sensitivity in Chinese adult patients with type 1 diabetes mellitus through hyperinsulinemic-euglycemic clamp technique. Methods Adult patients with type 1 diabetes mellitus （n=10,group T1DM） and age, sex, body mass index, waist and waist-hip ratio matched normal glucose tolerance subjects （n=10,group NGT） were recruited from the third affiliated hospital of Sun Yat-sen University between June 2011 and June 2013. There were 5 male and 5 female in each group. The average age was （27 ± 5） and （27 ± 8） yrs in each group,respectively. Hyperinsulinemic-euglycemic clamp were performed to measure glucose disposal rate as insulin sensitivity. Differences between groups were analyzed by Student′s t test. Results No significant differences were found in age, waist, waist-hip ratio, body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and uric acid between type 1 diabetes mellitus group and normal glucose tolerance group （t=-1.248-0.973, all P〉0.05）, except for glycated hemoglobin A1c （（7.5 ± 0.8）% vs （5.2 ± 0.3）%, t=-6.318, P〈0.001）. Glucose disposal rate in type 1 diabetes mellitus and normal glucose tolerance groups were （7.8±1.9） mg·kg-1·min-1 and （14.0±1.7） mg·kg-1·min-1 （t=7.769, P〈0.001）, respectively. Conclusion Insulin resistance may be present in Chinese patients with adult type 1 diabetes mellitus.

关 键 词：糖尿病 1型 胰岛素抵抗 高胰岛素-正葡萄糖钳夹技术 

分 类 号：R587.1[医药卫生—内分泌]