子宫内膜的“凤凰涅槃”之路——缺氧选择与子宫内膜异位症的病因转归初探  

Endometriosis is the survivor of reflux endometrium by hypoxia selection—As the phoenix nirvana, a regeneration story of endometrial cells

作　　者：鲁泽春[1] 李亚里[2] 

机构地区：[1]解放军第306医院妇产科,北京100101 [2]解放军总医院妇产科,北京100101

出　　处：《医学争鸣》2015年第2期23-28,共6页Negative

基　　金：国际子宫内膜异位症合作项目(HXZGNMYWZ)

摘　　要：子宫内膜异位症(EMs)研究近90年,病因依然成谜。EMs与月经紧密相关,月经期间子宫螺旋动脉收缩,内膜因缺血缺氧脱落,随经血逆流,在异位种植血管生成前,不可避免处于缺氧状态。近年研究表明缺氧改变细胞代谢、凋亡、增生、血管生成等各种生物学特性。本文重点阐述缺氧在EMs发生发展中的可能作用机制。The etiology of endometriosis is still an enigma after nearly 90-year study. Endometriosis is closely related to the menstruation, during which uterine spiral arteries contract and endometrium is shed due to ischemia and hypoxia. Endometrial cells that are misplaced along with menstrual reflux are in isehemic and hypoxic state until angiogenesis in the pelvic cavity. In fact, recent experimental and clinical studies have suggested that hypoxia affects a series of biological parameters like metabolism, apoptosis, proliferation and angiogenesis of cells. The article focuses on the role of hypoxia in the development of endometriosis, which may be able to provide a new perspective for the study and treatment of the disease.

关 键 词：子宫内膜异位症 缺氧 经血逆流 在位内膜 

分 类 号：R711[医药卫生—妇产科学]