腰椎间盘突出症中医证型与血清TNF-α水平相关性研究  

Correlation of TCM Syndrome and Serum TNF-αLevels in Patients with Lumbar Disc Herniation

作　　者：仇湘中[1] 蒋盛昶[1] 张信成[1] 唐皓[1] 夏爱民[1] 易振宇[1] 张旭桥 

机构地区：[1]湖南省中医药研究院附属医院,长沙410006 [2]湖南省湘潭市中医医院

出　　处：《中国中医骨伤科杂志》2015年第6期39-41,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖南省卫生厅中医药科研基金项目(201134)

摘　　要：目的:探讨血清肿瘤坏死因子-α(TNF-α)水平在腰椎间盘突出症中医证型的分布规律。方法 :采用前瞻性研究方法收集120例腰椎间盘突出症患者,按瘀血证、肾虚证、寒湿证、湿热证分为4组,观察比较各组血清TNF-α水平。结果:1)证型分布:瘀血证42例(35%),肾虚证33例(27.5%),寒湿证30例(25%),湿热证15例(12.5%);2)血清TNF-α水平按肾虚证组、寒湿证组、湿热证组、瘀血证组呈逐步增高趋势;3)血清TNF-α水平在腰椎间盘突出症中医各证型比较:瘀血证组与肾虚证组、寒湿证组比较差异均有统计学意义(P<0.01),寒湿证组与湿热证组、瘀血证组比较差异均有统计学意义(P<0.01),湿热证组与肾虚证组、寒湿证组比较差异均有统计学意义(P<0.01),肾虚证组与湿热证组、瘀血证组比较差异均有统计学意义(P<0.01),而瘀血证组与湿热证组;肾虚证组与寒湿证组比较差异无统计学意义(P>0.05)。结论:腰椎间盘突出症中医证型与血清TNF-α水平具有一定相关性,可用于辅助诊断中医证型。Objective：To explore the distribution of serum levels of TNF-αin different TCM syndromes types of lumbar disc herniation.Methods：120patients with LDH were divided into blood stasis syndrome,kidney deficiency syndrome,cold-dampness syndrome and damp-heat syndrome groups.The serum TNF-αlevels in each group were observed and compared.Results：1）Syndrome distribution：blood stasis syndrome 42cases（35%）,kidney deficiency syndrome 33cases（27.5%）,cold-dampness syndrome 30cases（25%）,damp-heat syndrome 15cases（12.5%）.2）Serum levels of TNF-αshowed a gradual increasing trend by kidney deficiency syndrome group,cold-dampness syndrome group,damp-heat syndrome group and blood stasis syndrome group.3）The difference of serum TNF-αlevel between blood stasis syndrome group and damp-heat syndrome group shows no statistically significant.And the difference of serum TNF-αlevel between kidney deficiency syndrome group and cold-dampness syndrome group shows no statistically significant too.The differences of serum TNF-αlevel among all the other groups were statistically significant（P〈0.01）.Conclusion：TCM syndrome and serum TNF-αlevels have some relevance in patients with LDH,which is useful in the diagnosis of the TCM Syndrome.

关 键 词：腰椎间盘突出症 中医证型 血清TNF-Α 

分 类 号：R681.5[医药卫生—骨科学]