芒硝外敷对腹腔炎症患者细胞因子的影响  

The application of the external treatment of Glauber′s salt on cytokines of acute pancreatitis patients

作　　者：毛祖泽 莫经刚[2] 

机构地区：[1]临海市第五人民医院,临海市桃渚中心卫生院普通外科,浙江省临海317013 [2]台州市中心医院普外科

出　　处：《中国基层医药》2015年第11期1626-1628,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省台州市科技资金项目（121KY09）

摘　　要：目的：探讨芒硝外敷应用在腹腔炎症患者中对细胞因子的影响及临床应用价值。方法回顾性分析180例急性胰腺炎患者的临床资料，根据治疗方案不同分为观察组和对照组，对照组采用西医常规治疗，观察组联合芒硝外敷治疗，记录两组患者临床治疗效果。结果观察组治疗总有效率为92．22％，对照组治疗总有效率为82．22％，两组差异有统计学意义（χ2＝4．037，P ＜0．05）。观察组治疗后 TNF-α（40．02±5．19）ng／L、IL-6（32．93±7．65）ng／L、IL-8（23．41±3．86）ng／L、NF-kb（85．36±19．65）U ／L；对照组治疗后 TNF-α（63．38±8．97）ng／L、IL-6（56．73±11．16）ng／L、IL-8（40．85±7．43）ng／L、NF-kb （231．32±41．28）U ／L，两组间比较差异均有统计学意义（t ＝21．384、16．687、19．760、30．287，均 P ＜0．05）。观察组腹胀缓解时间（3．18±1．33）d，胃肠功能恢复时间（5．64±1．86）d，住院时间（15．13±3．76）d；对照组腹胀缓解时间（5．64±2．31）d，胃肠功能恢复时间（8．96±3．45）d，住院时间（24．59±5．87）d；两组间比较差异均有统计学意义（t ＝8．755、8．035、12．874，均 P ＜0．05）。结论采用芒硝外敷应用在腹腔炎症患者可以有效减轻体内炎性反应，提升治疗效果，加快患者胃肠功能恢复，值得在临床上推广应用。Objective To discuss the application of glauber＇s salt external impact on cytokines in patients with celiac inflammation and clinical application value.Methods Clinical data of 180 patients with acute pancreatitis were retrospectively analyzed.According to the different treatment,they were divided into the observation group and control group,the control group were treated by routine western medicine,the observation group were treated with mirabilite topical therapy,records of two groups of patients with clinical therapeutic effect.Results The total effective rate of the observation group was 92.22%,which of the control group was 82.22%.The differences between the two groups was statistically significant （χ2 =4.037,P 〈0.05）.The cytokines concentrations of the observation group after treatment were as follows：TNF alpha （40.02 ±5.19）ng/L,IL -6 （32.93 ±7.65）ng/L,IL -8 （23.41 ±3.86）ng/L, NF -κB （85.36 ±19.65）U /L;those in the control group after treatment：TNF alpha （63.38 ±8.97）ng/L,IL -6 （56.73 ±11.16）ng/L,IL -8 （40.85 ±7.43）ng/L,NF -κB （231.32 ±41.28）U /L,statistical analysis showed that contrast differences among groups with statistical significance （t =21.384,16.687,19.760,16.687,all P 〈0.05）.The observation group （3.18 ±1.33）d abdominal distension relief time,gastrointestinal function recovery time （5.64 ±1.86）d,length of hospital stay （15.13 ±3.76）d;The control group （5.64 ±2.31）d abdominal distension relief time,gastrointestinal function recovery time （8.96 ±3.45）d,length of hospital stay （24.59 ±5.87）d;Statisti-cal analysis showed that contrast differences among groups with statistical significance（t =8.755,8.035,12.874,all P 〈0.05）.Conclusion Using glauber＇s salt topical application in patients with celiac inflammation can effectively reduce inflammation in the body,improve the treatment effect,to speed up the patients with gastrointestinal functional recovery,which is worth popularization and application in cli

关 键 词：芒硝 外敷 腹腔炎症 细胞因子 

分 类 号：R259[医药卫生—中西医结合]