黄芪注射液辅助抗结核药治疗复治肺结核疗效观察  

Curative Effect on Retreated Tuberculosis Adjuvant Therapy by Astragalus Membranaceus Injection with Anti Tuberculosis Drugs

作　　者：章期生 徐金田[2] 郑德明 

机构地区：[1]淳安县第一人民医院感染科,浙江淳安311700 [2]杭州市第二人民医院结核科

出　　处：《药物流行病学杂志》2015年第6期354-355,363,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨黄芪注射液辅助抗结核药治疗复治肺结核的疗效及不良反应。方法:复治120例肺结核患者随机分为观察组与对照组各60例。对照组单纯予抗结核药治疗,观察组在对照组基础上加用黄芪注射液辅助治疗。观察治疗后两组患者痰菌转阴、肺部病灶吸收、空洞闭合及不良反应发生情况等。结果:治疗后,观察组的痰菌转阴率均明显高于对照组,总吸收率也明显高于对照组(P<0.05)。两组X线胸片空洞病变情况比较,差异有统计学意义(P<0.05)。观察组药品不良反应发生率明显低于对照组(P<0.05)。结论:黄芪注射液辅助抗结核药治疗肺结核疗效显著,能明显提高痰菌转阴率、总吸收率,显著改善X线胸片空洞情况,降低药品不良反应,值得临床上进一步推广应用。Objective： To study the curative effect and the adverse reactions on retreated tuberculosis treated by astragalus membranaceus injection adjuvant to anti-tb drugs. Methods： 120 cases of patients with retreated tuberculosis were divided into observation group and control group with 60 cases of patients in each group at random. Control group was treated with anti-tb drug, observation group was treated with stragalus membranaceus injection on the basic of control group, and the sputum bacteria turn to negative, lung lesions absorption, cavity closure and the occurance of adverse reac- tions of the patients in the two groups were observed. Results ：The rate of sputum bacteria turned to negative, lung lesions absorption of the patients in the observation group were all much higher than the control group（P 〈0.05） ; On the chest X- ray cavity lesions, there was significant statistical difference between the two groups （P 〈 0.05） ;The incidence of adverse reactions of the observation group was obvilously lower than that of control group （ P 〈 0.05 ）. Conclusion： Astragalus membranaceus injection adjuvant to anti-tb drugs, has signigicant curative effect on the treatment of tuberculosis , it also can improve the cure rate and reduce the adverse reaction, so it was worthy of further clinical application.

关 键 词：黄芪注射液 肺结核 抗结核药物 药品不良反应 

分 类 号：R286[医药卫生—中药学]