芬兰某市青春期女童血清C-反应蛋白体脂总量变化趋势及相关性  

Growth pattern and correlation of C-reactive protein and total fat mass in girls during pubertal growth

作　　者：温鑫菲[1] 王人卫[2] 冯国双[3] 刘阳[2] 程蜀琳[4,5] 

机构地区：[1]东华大学体育部,上海201620 [2]上海体育学院运动科学学院运动医学教研室 [3]中国疾病预防控制中心公共卫生监测与信息服务中心 [4]上海交通大学体育系 [5]Department of Health Science,University of Jyvskyl

出　　处：《中国学校卫生》2015年第5期658-662,共5页Chinese Journal of School Health

基　　金：上海市人类运动能力开发与保障重点实验室项目(11DZ2261100);芬兰科学院SKID-KID项目(#135038);上海交通大学致远讲席教授基金;中央高校基本科研业务费专项资金资助项目;东华大学人文社科基金培育项目(15D111110)

摘　　要：目的观察青春期前（即生长突增前期）至成年早期女童体内血清C-反应蛋白水平和体脂总量的变化情况,探讨两者是否具有循轨特征及两者之间的关系。方法对396名芬兰于韦斯屈莱市及周边的9-13岁健康女孩进行为期7 a追踪研究。采用酶联免疫吸附法检测女孩血清C-反应蛋白水平,采用双能X-线吸收仪检测其体脂含量。利用MLwin软件分别对女孩体内C-反应蛋白水平和体脂总量的总体变化趋势进行拟合。结果青春期女孩体内血清C-反应蛋白水平和体脂总量均随年龄增长呈上升趋势（C-反应蛋白水平随年龄增长依次为5.2,5.3,5.5,6.1 ng/m L,体脂总量随年龄增长依次为10.1,13.7,15.4,19.4 kg）,且具有循轨特征,二者之间存在正相关（R^2=0.210,P〈0.01）。结论在儿童期体脂含量较高的人,其成年后患代谢性相关疾病的风险可能较高。Objective To investigate changes of serum C-reactive protein （CRP） and whole body fat mass （FM） in girls during the transition from pre-puberty to early adulthood. Methods A 7-year follow-up study of 396 healthy Finnish girls aged 11.2 years at the baseline. Serum concentration of CRP was assessed by using enzyme-linked immunosorbent assay. Body FM was measured with dual-energy X ray densitometry（DXA）. Results CRP and FM increased with age from pre-puberty to early adulthood, the increasement of CPR was 5.2, 5.3, 5.5 and 6.1 ng/mL; of FM was 10.1, 13.7, 15.4 and 19.4 kg respectively, and both CRP and FM correlated with each other（R^2 =0.210, P〈0.01 ）. Conclusion Individual who has higher body fat percentage during childhood might have higher risk of metabolic disorders in adulthood.

关 键 词：青春期 C-反应蛋白质 儿童 体脂分布 

分 类 号：R179[医药卫生—妇幼卫生保健] R195[医药卫生—公共卫生与预防医学]