新型海藻酸盐湿性敷料的制备及其生物相容性  

Preparation and Biocompatibility of Novel Hisorb~ Alginate Dressing

作　　者：张珠[1] 易继凌[2] 殷义霞[2] 李世普[2] 

机构地区：[1]武汉理工大学校医院,湖北武汉430070 [2]武汉理工大学材料复合新技术国家重点实验室,湖北武汉430070

出　　处：《武汉大学学报（理学版）》2015年第3期208-212,共5页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金青年基金(51403168;51172172);国家重点基础研究发展计划(973)项目(2011CB606205);湖北省自然科学基金(2013CFB354)资助项目

摘　　要：采用湿法纺丝制备藻酸盐纤维,然后经过纱布织造工艺制备藻酸盐纱布(简称Hisorb?),比较了Hisorb?与3种常见市售敷料(简称G-CP,G-LR,G-AB)浸提液的体外相关生物学特性,考察了各敷料浸提液的细胞毒性、迁移率、溶血性及红细胞渗透脆性.实验结果表明,Hisorb?无细胞毒性且能促进细胞增殖,无溶血现象,对红细胞的渗透脆性有一定的保护作用,具有潜在的促进伤口愈合的性能.A novel alginate gauze（Hisorb？）was weaved by advanced techniques and preparation after the alginate fiber fabricated by wet spinning process.Biological properties of Hisorb？and three common commercial dressings（GCP,G-LR,G-AB in abbreviation）were comparatively analyzed in vitro.The cytotoxicity,migration rate of fibroblast cells,hemocompatibility and osmotic fragility of RBC（red blood cell）were evaluated by MTT test,wound healing assay,blood compatibility analyzation respectively.The results show that Hisorb？has no cytotoxicity and could promote cell proliferation.No hemolysis was observed during the experiment.Hisorb？gauze could maintain the osmotic fragility of cell and stimulate cell migrations.It has potential value in healing wounds.Hisorb？gauze was expected to be a clinical dressing.

关 键 词：藻酸盐敷料 湿性愈合材料 细胞毒性 血液相容性 细胞渗透脆性 

分 类 号：Q81[生物学—生物工程]