微波辅助煅烧合成双相磷酸钙纳米颗粒  

Microwave Assisted-Sintering Synthesis of Biodegradable and Cytocompatible Biphasic Calcium Phosphate Nanoparticles

作　　者：尹杉杉[1] 孙杰[1] 张玉峰[2] 李玫 邓克俭[1] 

机构地区：[1]中南民族大学化学与材料科学学院/催化材料科学国家民委教育部重点实验室,湖北武汉430074 [2]武汉大学口腔医学院/口腔生物医学工程教育部重点实验室,湖北武汉430072 [3]布里斯托尔大学有机化学中心

出　　处：《武汉大学学报（理学版）》2015年第3期229-233,共5页Journal of Wuhan University:Natural Science Edition

基　　金：教育部新世纪优秀人才支持计划(NCET-13-1047);武汉市关键技术攻关计划(2014060202010129);中南民族大学基金(CZW14031)资助项目

摘　　要：采用微波辅助反应联用煅烧法制备纳米级的双相磷酸钙(BCP)颗粒,讨论了微波辅助过程中样品的组成变化,对不同温度煅烧制备的BCP样品进行了表征,并对其细胞相容性和生物降解性进行了评价.结果表明,通过本途径能将BCP纳米颗粒的制备过程缩短至8h,通过改变煅烧温度条件能有效调节BCP纳米颗粒的成分组成;3种HA百分含量分别为100%,89.9%和57.9%的BCP纳米颗粒均具有较好的细胞相容性和生物降解性.Nanopowders of biphasic calcium phosphate（BCP）composites were prepared using microwave assistedsintering synthesis route.The phase transformation of the microwave irradiation was investigated.The chemical and phase composition,morphology and particle size of the samples were characterized.Cytocompatibility and biodegradability were also evaluated.Results show that the microwave irradiation shortened the formation time of the BCP to less than 8h.The variation of relative index ratio（RIR）differs at different sintering temperatures,three kinds of BCP nano-particles consisted different hydroxyapatite ratio,100%,89.9% and 57.9% was synthesized.All above mentioned BCP nanoparticles are found to be biocompatible and in vitro dissolvable.

关 键 词：双相磷酸钙 微波辅助联用煅烧法 细胞相容性 生物降解性 纳米颗粒 

分 类 号：R318.08[医药卫生—生物医学工程]