盐酸多西环素注射液在猪体内残留消除规律研究  

Residue Depletion Study of Doxycycline Hydrochloride Injection in Swine

作　　者：黄耀凌[1] 王亦琳[1] 徐倩[1] 毕言锋[1] 胡海燕[1] 白玉惠[1] 李丹[1] 徐士新[1] 

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2015年第6期28-32,共5页Chinese Journal of Veterinary Drug

基　　金：国家十二五农村领域科技计划课题(863计划)(2011AA10A214)

摘　　要：为研究自制盐酸多西环素注射液在猪体内的残留消除规律,以10 mg/kg剂量给健康猪肌内注射盐酸多西环素注射液,每日1次给药,连续三次。在最后一次给药后7、14、21、28和35 d时间点采集肌肉、肝脏、肾脏、脂肪和注射部位肌肉,用UPLC-MS/MS法测定组织中多西环素残留量。结果表明,给药35 d后,肌肉、肝脏、肾脏、脂肪和注射部位肌肉中的多西环素残留量分别为18、24、69、10、59μg/kg,均低于最高残留限量。用WT1.4软件计算休药期,盐酸多西环素注射液在猪肌肉、肝脏、肾脏、脂肪和注射部位肌肉中的休药期分别为33.9、23.8、24.8、0和36.9 d,为保证兽药安全使用、消费者身体健康与食品安全,建议盐酸多西环素注射液在猪的休药期为42 d。The residue depletion of self- made doxycycline hydrochloride injection in the swine tissues was studied.The preparation was administered intramuscularly at a dose of 10 mg / kg for 3 times,once daily,and pigs were slaughtered for collecting tissue samples at 7,14,21,28 and 35 day after the last administration. The result showed that the doxycycline concentrations in muscle,liver,kidney,fat and muscle of inject site at 35 day were18,24,69,10 μg / kg and 59 μg / kg,respectively. Then the concentration time data of doxycycline were analyzed by WT1. 4 software. It suggested that the withdrawal time of doxycycline hydrochloride injection in swine be 42 day.

关 键 词：多西环素 残留消除 猪 休药期 

分 类 号：S859.83[农业科学—临床兽医学]