老年代谢综合征患者血清Apelin水平的变化及相关分析  

The Changes of Serum Apelin Level in Elderly Patients with Metabolic Syndrome and its Correlation Analysis

作　　者：方芳[1] 扈友庄[1] 郑桂凤[1] 王俊贤[1] 陈恺[1] 

机构地区：[1]广东医学院附属医院老年病科,广东湛江524001

出　　处：《辽宁医学院学报》2015年第3期10-12,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：湛江市科技攻关资助项目;项目编号:2013B01129

摘　　要：目的探讨老年代谢综合征患者体内Apelin水平的变化,以及Apelin与胰岛素抵抗的相互关系。方法实验分为老年代谢综合征组80例及正常对照组30例。用ELISA的方法检测血清Apelin水平,同时测量身高、体重、腰围、空腹胰岛素、血糖、血脂。老年代谢综合征组按BMI(Body Mass Index体重指数)为28,分为代谢综合征肥胖组和非肥胖组。结果 (1)老年代谢综合征肥胖组、非肥胖组空腹血清Apelin较正常对照组明显升高[(452.63±20.27,401.76±26.71)vs(368.23±18.19)ng/L,P<0.01];(2)老年代谢综合征肥胖组空腹血清Apelin较非肥胖组升高[(452.63±20.27)vs(401.76±26.71)ng/L,P<0.05];(3)相关性分析:Apelin与HOMA-IR、FINS、BMI、TG、TC、LDL呈正相关,与HDL呈负相关。结论 Apelin与肥胖、胰岛素抵抗相关,改善胰岛素抵抗,如何降低患者血清Apelin水平可能将成为代谢综合征治疗新的药物治疗靶点。Objective To investigate the changes of the Apelin level in elder patients with metabolic syndrome and analyze the correlation between Apelin and insulin resistance. Methods Fasting blood serum Apelin was measured in 110 cases,80 cases of old age patients with metabolic syndrome and 30 cases of the normal（ the control group）,specifically. Such data as the height,weight,waist,fasting insulin,glucose and blood lipid of these cases were measured. The old age group with metabolic syndrome were divided into two groups at the 28 point of BMI. Results（ 1） Serum Apelin concentration in the elderly obesity group with metabolic syndrome and the non- obesity group was higher than that in control group [（ 452. 63 ± 20. 27,401. 76 ± 26. 71） vs（ 368. 23 ± 18. 19）ng / L,P〈0. 01].（ 2） Serum Apelin concentration in in the elderly obesity group with metabolic syndrome was higher that in the non- obesity group [（ 452. 63 ± 20. 27） vs（ 401. 76 ± 26. 71） ng / L,P〈0. 05].（ 3） Partial correlation analysis showed that Apelin was positively correlated with HOMA- IR,FINS,BMI,TG,TC,LDL and negatively correlated with HDL. Conclusion Apelin is related with obesity and insulin resistance. How to improve insulin resistance and reduce the level of serum Apelin in patients with metabolic syndrome may become new targets for drugs.

关 键 词：APELIN 代谢综合征 胰岛素抵抗 血脂 

分 类 号：R589[医药卫生—内分泌]