冠心病患者中医证型与脑钠肽、左室射血分数及E/A的相关性分析  

Correlation analysis of traditional Chinese medicine syndrome type,brain natriuretic peptide,left ventricular ejection and E/A in coronary heart disease patients

作　　者：赵振凯[1,2] 王永刚[3,2] 郑刚[3,2] 钟伟[3,2] 尚俊平[3,2] 齐婧[3,2] 高政涛 李欣[1,2] 张志国[1] 

机构地区：[1]陕西中医学院,陕西咸阳712000 [2]陕西中医学院心脑血管病研究所,陕西咸阳712000 [3]陕西中医学院第二附属医院心脑血管病中心,陕西咸阳712000

出　　处：《长春中医药大学学报》2015年第3期525-528,共4页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金(30901895);国家中医临床研究基地业务建设科研专项(JD2X2012144);国家中医药管理局重点专科心血管病科建设项目;国家中管局重点学科中西医结合临床建设项目;陕西省中管局科研项目(13-LC063);陕西省教育厅科学研究计划(2013JK0814);陕西省第五批重点专科心脑血管病科建设项目

摘　　要：目的探讨冠心病患者中医证型与脑钠肽(BNP)、左室射血分数(LVEF)及E/A的相关性。方法统计386例冠心病患者中医证型和BNP、LVEF及E/A的数值,与同期体检健康者20例作比较,分析各中医证型与BNP、LVEF及E/A的关系。结果中医证型以心血瘀阻证及痰阻心脉证为主。与正常组比较,冠心病患者中医证型BNP水平均显著升高(P<0.01),LVEF各证型均明显降低(P<0.01),E/A各证型均明显降低(P<0.01);组间比较,BNP以心肾阳虚证最高(P<0.01),依次为痰阻心脉证、心血瘀阻证>寒凝心脉证、气滞心胸证>心气亏虚证>心阴不足证;LVEF以心肾阳虚证最低(P<0.01),心血瘀阻证次之(P<0.01),余各证型间无统计学意义(P>0.05);E/A以心肾阳虚证最低(P<0.01),心气亏虚证次之(P<0.05),余各证型间无统计学意义(P>0.05)。BNP与LVEF呈负相关(P<0.05),与E/A呈负相关(P<0.05)。结论冠心病中医证型与BNP、LVEF及E/A具有一定相关性,BNP与LVEF、E/A呈负相关,三者联合测定可以作为冠心病病情变化的参考指标。Objective To research the correlation among traditional Chinese medicine syndrome type and brain natriuretic peptide （BNP）, left ventricular ejection（LVEF）, E/A in coronary heart disease patients. Methods By separately summa-rizing the data of 386 cases of coronary heart disease with their BNP, LVEF and E/A with TCM syndrome type, comparing the resuhs with homochromous 20 cases physical examination, then analyzing the relations between TCM syndrome type and BNP, LVEF, E/A. Results Syndrome of TCM mainly oriented with heart blood stasis syndrome and phlegm stasis syn- drome; Compared with control, BNP were increased in patients with coronary heart disease （P 〈 0.01）, LVEF of each card type were significantly lower （ P 〈 0.01）, and E/A of each syndrome were significantly lower（ P 〈 0.01） ; The BNP of heart and kidney yang deficiency syndrome is highest （ P 〈 0.01 ）, followed by phlegm heart pulse syndrome, blood stasis resis- tance 〉 haemorrheological nature heart pulse syndrome, qi and mind 〉 heart qi deficiency syndrome 〉 heart yin deficien- cy syndrome; The LVEF of heart and kidney yang deficiency syndrome is the lowest （P 〈 0.01）, blood stasis resistance syn- drome followed（ P 〈 0.01） ） ,the last syndrome types have no obvious difference （ P 〉 0.05） ; The E/A of heart and kidney yang deficiency syndrome is the lowest （ P 〈 0.01 ）, heart qi deficiency syndrome followed （ P 〈 0.05）, the last syndrome types have no obvious difference （ P 〉 0.05） .The BNP was negative correlation with LVEF（ P 〈 0.05） ,and negatively cor- related with E/A（ P 〈 0.05）. Conclusion Coronary heart disease of TCM syndrome types and BNP, LVEF and E/A has certain relevance, the BNP was negative correlation with LVEF, E/A. Combined measurement can be a reference index of coronary heart disease condition changes.

关 键 词：冠心病 中医证型 脑钠肽 左室射血分数 E/A 

分 类 号：R256.22[医药卫生—中医内科学]