2型糖尿病患者与正常人群体内DPP4活性水平研究  

Research of DPP4 activity level between type 2 diabetes and normal group

作　　者：高平[1] 马晓英[1] 陈玲[1] 陆雷群[1] 

机构地区：[1]上海瑞金医院卢湾分院内分泌科,200020

出　　处：《中国现代医药杂志》2015年第1期41-43,共3页Modern Medicine Journal of China

摘　　要：目的研究正常人群组与2型糖尿病患者空腹及餐后2h血清DPP4活性水平。方法正常人群组29例及2型糖尿病组83例,分别记录BMI、空腹及餐后2h血糖和C肽水平,并分别测定空腹及餐后2h血清DPP4活性水平。结果正常人群组空腹DPP4活性水平为(540.58±160.22)pmol/min,餐后2h为(508.32±203.58)pmol/min;0min和120min之间无差异(P>0.05);2型糖尿病组空腹DPP4活性水平为(583.12±289.28)pmol/min,餐后2h为(638.65±316.19)pmol/min;0min和120min之间有差异(P<0.05);其中2型糖尿病组和正常人群组在0min的DPP4水平(P<0.05)及120min的DPP4水平(P<0.05)均有统计学差异。结论在正常人群中,其血清DPP4的活性水平不随进食即血糖的改变而发生变化,而在2型糖尿病患者中,无论其空腹还是餐后血清DPP4活性水平均要高于正常人群组血清DPP4的活性水平,并且随进食即血糖的改变而发生变化。Objective To research normal group and the patients with type 2 diabetes fasting and postprandial serum DPP4 activity level. Methods Recorded the BMI of 29 cases in normal group and 83 cases in type 2 diabetes group , fasting and postprandial blood glucose and c-peptide levels, and determination of fasting and postprandial serum DPP4 activity level. Results There was no difference between fasting and postprandial DPP4 activity levels in normal group （P〉0.05）. There was significant difference between fasting and postprandial DPP4 activity levels in type 2 diabetes group （P〈0.05）. Fasting and post-prandial DPP4 level were statistically significant between normal group and type 2 diabetes group. Conclusion In normal group, the level of serum DPP4 do not change with the level of glucose. But in type 2 diabetes group, their fasting and post-prandial serum DPP4 activity levels are higher than those in normal group, and change with the lever of glucose.

关 键 词：2型糖尿病 DPP4 血糖 C肽 

分 类 号：R587.1[医药卫生—内分泌]