Targeted inductive heating of nanomagnets by a com- bination of alternating current （AC） and static magnetic fields  

作　　者：Ming Ma Yu Zhang Xuli Shen Jun Xie Yan Li Ning Gu 

机构地区：[1]State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and MedicalEngineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nan]ing 210096, China

出　　处：《Nano Research》2015年第2期600-610,共11页纳米研究（英文版）

摘　　要：The conversion of electromagnetic energy into heat by nanomagnets has the potential to be a powerful, non-invasive technique for cancer therapy by hyperthermia and hyperthermia-based drug release, while temperature controllability and targeted heating are challenges to developing applications of such magnetic inductive hyperthermia. This study was designed to control the hyperthermia position and area using a combination of alternating current （AC） and a static magnetic field. MnZn ferrite （MZF） nanoparticles which exhibited excellent hyperthermia properties were first prepared and characterized as an inductive heating mediator. We built model static magnetic fields simply using a pair of permanent magnets and studied the static magnetic field distributions by measurements and numerical simulations. The influence of the transverse static magnetic fields on hyperthermia properties was then investigated on MZF magnetic fluid, gel phantoms and SMMC-7721 cells in vitro. The results showed a static magnetic field can inhibit the temperature rise of MZF nanoparticles in an AC magnetic field. But in the uneven static magnetic field formed by a magnet pair with repelling poles face-to-face, the heating area can be restricted in a central low static field; meanwhile the side effects of hyperthermia can be reduced by a surrounding high static field. As a result we can position the hyperthermia area, protect the non-therapeutic area, and reduce the side effects lust by using a well-designed combination of AC and static field.进由 nanomagnets 的热的电磁的精力的变换有潜力是为由过高热和基于过高热的药版本的癌症治疗的一种强大的、非侵略的技术，当时温度可控制性并且加热指向是对开发如此的磁性的引入的过高热的应用程序的挑战。这研究被设计用交流电(交流) 和一个静态的磁场的联合控制过高热位置和区域。展出了优秀过高热性质的 MnZn 铁酸盐(MZF ) nanoparticles 首先作为一个引入的加热调停人被准备并且描绘。我们造了简单地使用一双永久磁铁的模型静电干扰磁场并且由大小和数字模拟学习了静态的磁场分布。过高热性质上的横向的静态的磁场的影响然后在 vitro 在 MZF 磁性的液体，胶化幽灵和 SMMC-7721 房间上被调查。结果证明一个静态的磁场能在一个交流磁场禁止 MZF nanoparticles 的温度上升。但是在不平的静电干扰，磁场与面对面排斥杆由磁铁对形成了，加热区域能在一个中央低静态的领域里被限制；同时，过高热的副作用能由一个包围高静态的领域被减少。作为结果，我们能放过高热区域，保护非治疗学的区域，并且减少就由使用交流和静态的地的设计得好的联合的副作用。

关 键 词：HYPERTHERMIA magnetic nanoparticles static magnetic field alternating magnetic field MnZn ferrite 

分 类 号：TM924.5[电气工程—电力电子与电力传动] TF777[冶金工程—钢铁冶金]