Toll样受体4与糖尿病肾病的发病机制相关性的研究进展  

Progress in search for relationship between Toll like receptor 4 with the pathogenesis of diabetic nephropathy

作　　者：常微微[1] 贺连平[1] 姚应水[1] 

机构地区：[1]皖南医学院公共卫生学院,安徽芜湖241002

出　　处：《中国临床药理学杂志》2015年第11期1066-1068,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81441127)

摘　　要：至今为止,糖尿病肾病的病因及其发病机制尚不明确。近年来大量研究表明,炎症在糖尿病肾病发生和持续进展中起关键作用。Toll样受体4可通过髓样分化因子88(My D88)以依赖性和非依赖性等途径激活下游信号分子,引发促炎症细胞因子的释放而发挥免疫应答效应。本文就糖尿病肾病发病炎症的机制及其与Toll样受体4的关系做一综述。So far, the etiology and pathogenesis of diabetic nephropathy have not been clear.Recent studies indicated that inflammatory factors play important roles in the pathogenesis and development of diabetic nephropathy.While Toll like receptor 4 can activate the downstream sig-nal molecules through the myeloid differentiation factor 88 （ MyD88 ） depen-dent and the MyD88 independent pathway, so as to induce immune responses.This article makes a new survey on the pathogene-sis of diabetic nephropathy inflammation and its relationship with Toll like receptor 4.

关 键 词：糖尿病肾病 TOLL样受体4 炎症 

分 类 号：R587.2[医药卫生—内分泌] R363[医药卫生—内科学]