丹红注射液对ACS患者PCI术后血管内皮功能及炎性因子水平的影响  

Treatment of Danhong Injection with Atorvastatin on Endothelial Function and Inflammation Factors in Patients with Acute Coronary Syndrome After Percutaneous Coronary Intervention

作　　者：郭建峰[1] 吴胜本[1] 杨金平[1] 孙国栋 王云帆[3] 

机构地区：[1]滨州市人民医院,山东滨州256610 [2]淳安县第一人民医院,浙江淳安311700 [3]浙江省人民医院,杭州310014

出　　处：《中国实验方剂学杂志》2015年第12期154-157,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨丹红注射液对急性冠脉综合征(acute coronary syndrome,ACS)患者经皮冠状动脉介入治疗(PCI)术后血管内皮功能及炎性因子的影响。方法:选取2012年5月至2014年5月在本院收治的125例ACS患者作为研究对象,均接受冠状动脉介入治疗。随机分为对照组62例和观察组63例,两组均给予氯吡格雷、阿司匹林、β受体阻滞剂等常规治疗。对照组在常规治疗基础上给予阿托伐他汀治疗;观察组给予丹红注射液联合阿托伐他汀治疗。比较两组ACS患者治疗前后血管功能指标包括内皮素-1(ET-1),一氧化氮(NO),血管性血友病因子(v WF)和血流介导的内皮依赖性舒张功能(FMD),以及炎性因子包括肿瘤坏死因子-α(TNF-α),白细胞介素-1(IL-1)和C反应蛋白(CRP)的水平及并发症发生情况。结果:对照组与观察组患者治疗后血管内皮功能指标(ET-1,NO,v WF,FMD)相对治疗前均有所改善,且观察组比对照组改善程度更为显著,差异均具有统计学意义(P<0.05)。对照组与观察组患者治疗后TNF-α,IL-1以及CRP等炎性因子水平较治疗前均有所降低,同时与对照组相比,观察组的改善程度更佳(P<0.05)。观察组术后主要心脏不良事件发生率显著低于对照组患者(7.9%VS 32.3%),差异具有统计学意义(P<0.05)。结论:丹红注射液可显著改善ACS患者经皮冠状动脉介入治疗术后血管内皮功能,并降低其炎性因子水平,其机制值得进一步探讨。Objective： The purpose of this study was to investigate the clinical effect of Danhong injection with atorvastatin on endothelial function and inflammation factors in patients with acute coronary syndrome （ACS） after percutaneous coronary intervention （PCI） surgery, and provide clinical basis for ACS therapy. Method： From 2012/5 to 2014/5, we collected 125 ACS cases treated with PCI in our hospital and divided them into 2 groups randomly, with 62 cases in control group and 63 cases in observation group. Besides conventional treatment, the control group was treated with atorvastatin and the observation group was treated with danhong injection combined with atorvastatin. Before and after treatment, the indexes of endothelial function including endothelin-1 （ ET-1 ） , nitrogen monoxide （ NO ） ,von willebrand factor （vWF） and flow-mediated dilation （FMD） , inflammation factors including tumor necrosis factor-or （TNF-ot） , interleukin-1 （ IL-I ） and C reactive protein （CRP）, as well as complications were observed and compared. Result： Compared with those before treatment, the indexes of endothelial function including ET-1, NO, vWF and FMD were all improved after treatment. However, these indexes decreased more significantly in the observation group than in the control group, and all differences were statistically signi~!cant （P 〈 0.05）. The inflammation factors including TNF-a, IL-1 and CRP were all decreased after treatment in both groups. However, those decreased more significantly in the observation group than in the control group, with all differences statistically significant （P 〈 0.05）. Complications in the observation group was significantly lower than in the control group （7.9% VS 32.3% , P 〈 0.05 ）. Conclusion： Combination treatment of danhong injection and atorvastatin for ACS therapy can improve endothelial function and decrease inflammation factors and is worthy of study and further application in clinical treatment.

关 键 词：丹红注射液 阿托伐他汀 急性冠脉综合征 C反应蛋白 

分 类 号：R287.6[医药卫生—中药学]