前列腺炎样症状与血清免疫球蛋白的关系  

The associations between prostatitis-like symptoms and serum level of immunoglobulin

作　　者：孙秀斌[1] 陈凯[1] 徐光玉[1] 王世平[1] 孟庆荣[1] 吕涛[1] 门同义[2] 

机构地区：[1]山东省莱芜市人民医院泌尿外科,271100 [2]山东大学附属千佛山医院泌尿外科

出　　处：《中华实验外科杂志》2015年第6期1306-1309,共4页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨男性人群中血清免疫球蛋白与前列腺炎样症状的相关性.方法 通过调查统计2012年6月至2012年12月在莱芜市人民医院和山东大学附属千佛山医院健康体检的成年男性,最终纳入1 500例.通过问卷调查采集社会人口学资料和生活方式特点.抽静脉血测定血清IgA、IgG 、IgM.前列腺炎样症状通过美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）来确认.结果 成年男性中前列腺炎样症状的患病率为10.1％.在Logistics回归分析模型中,校正年龄、吸烟、运动、教育水平等混杂因素后,可见随着血清IgA水平升高,中度或重度前列腺炎样症状发病风险逐渐升高[比值比（OR）=1.61,95％可信区间（CI）：1.09～2.38;OR=1.90,95％CI：1.30～2.78],并且IgA最高组（＞2.96g/L）还明显增加了疼痛症状（OR=1.89,95％ CI：1.13 ～3.13）和排尿症状发病风险（OR =2.16,95％ CI：1.36 ～3.45）;而IgG和IgM与前列腺炎样症状及其个体成分症状的发生无明显相关（P＞0.05）.结论 男性人群前列腺炎样症状有较高的患病率.升高的IgA与中度或重度前列腺炎样症状相关,说明免疫反应参与慢性前列腺炎的疾病过程,并与其症状严重程度相关.Objective To investigate the association between serum level of immunoglobulin and prostatitis-like symptoms.Methods Data were collected from the People＇ s Hospital of Laiwu City and Shandong provincial Qianfoshan Hospital （Random sampling） from June 2012 to November 2012,and 1500 subjects were included finally.Data on demographic characteristics and lifestyle characteristics were collected using a standardized questionnaire.Blood samples were obtained,and serum levels of immunoglobulin G （IgG）,immunoglobulin A （IgA） and immunoglobulin M （IgM） were measured.Prostatitis-like symptoms were defined based upon the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI）.The statistical analyses were performed by SPSS 13.0.Results The prevalence of prostatitis-like symptoms was 10.1％ in our study.After adjustments for potential confounding factors （age,smoking,alcohol drinking,physical activity and education） in the logistic regression model,with increased level of IgA,the higher risk of moderate and severe prostatitis-like symptoms [odds ratio （OR） =1.61,95％ confidence interval （CI）：1.09-2.38;OR =1.90,95％ CI：1.30-2.78] could be observed.In addition,the highest IgA significantly increased the pain symptoms （OR =1.89,95％ CI：1.13-3.13） and voiding symptoms （OR =2.16,95％ CI：1.36-3.45）.However,there was no statistically significant correlations between serum IgG and IgM levels with overall prostatitis-like symptoms or individual symptoms.Conclusion Prostatitis-like symptoms are a common disease in adult men.The relationship between elevated serum IgA levels and increased odds of moderate or severe symptoms indicates that immune response may participate in the etiology of chronic prostatitis.

关 键 词：血清免疫球蛋白 美国国立卫生研究院慢性前列腺炎症状指数 前列腺炎样症状 

分 类 号：R697.33[医药卫生—泌尿科学]