LncRNA在动物科学中的研究进展  

Research Progress on LncRNA in Animal Science

作　　者：赵健康[1] 臧长江[1] 姜保春[2] 

机构地区：[1]新疆农业大学动物科学学院,乌鲁木齐830052 [2]南通大学航海医学研究所,南通226001

出　　处：《中国畜牧兽医》2015年第6期1424-1428,共5页China Animal Husbandry & Veterinary Medicine

摘　　要：长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200nt的非编码RNA,能够存在于细胞核和细胞质中。LncRNA能够以顺式和反式作用方式调节基因表达,是一类重要的基因表达调节分子。LncRNA参与细胞分化发育、X染色体失活、肿瘤、免疫、神经系统和心血管系统疾病等多种生物过程和疾病的调控,具有重要的研究价值。作者主要对LncRNA的分类和来源、作用机制、研究现状及其在畜牧兽医中的研究情况进行了综述,为LncRNA在兽医和畜牧业科学中的研究和应用提供参考。Long noncoding RNA （LncRNA） constituted a novel class of non-protein coding tran- scripts longer than 200 nt, and were localized in nuclear and cytoplasmic. LncRNA can regulate gene expression in cis and trans,were recognized as a kind of key regulatory molecules. LncRNA were involved in various aspects of cell biology and disease, such as cell differentiation, X chromo- some inactivation, cancer, immune, neurological and cardiovascular system disorders. In this pa- per, we mainly summarized the origions, research status and action mechanism of LncRNA, as well as overseas and domestic research status of LncRNA in animal husbandry and veterinary. Finally, the potential research and application prospects of LncRNA in animal science were put forward.

关 键 词：长链非编码RNA 基因表达调控 发育 免疫 

分 类 号：Q522[生物学—生物化学]