复方玄驹胶囊对免疫性关节炎大鼠血清TNF-α和IL-1β的影响  

Effect of Fufang Xuanju Capsule on Serum TNF-α and IL-1β of Immunologic Arthritis Rats

作　　者：王远 张会娟 刘蓉 张斌[2] 

机构地区：[1]青岛市第九人民医院,山东青岛266000 [2]青岛大学附属医院,山东青岛266000

出　　处：《今日药学》2015年第5期334-337,共4页Pharmacy Today

摘　　要：目的观察复方玄驹胶囊对免疫性关节炎大鼠血清中TNF-α与IL-1β表达的影响,并初步探讨其治疗机制。方法建立Ⅱ型胶原蛋白诱导大鼠免疫性关节炎模型,观察复方玄驹胶囊对实验性大鼠体重增长速度和足肿胀的影响;检测血清IL-1β和TNF-α的水平。结果服用复方玄驹胶囊28 d后,模型大鼠体重增长速度明显增加,关节肿胀程度明显减轻(P<0.05或P<0.01);模型大鼠血清TNF-α与IL-1β水平降低(P<0.01)。结论复方玄驹胶囊在免疫性关节炎大鼠中可以下调致炎因子TNF-α与IL-1β的水平,提示这可能与该药抑制实验性类风湿性关节炎病情进展密切相关。OBJECTIVE To observe the therapeutic effect of decoction of Fufang Xuanju capsule on immunologic arthritis and investigate the mechanism of this drug on the disease by determining the expression of serum TNF-α and IL-1β in synovial tissues of joint. METHODS The experimental rat model of type Ⅱ collagen-induced arthritic（ CIA） was established. The growth rate of body weight and the inhibitory effects on paw edema were observed,and serum TNF-α and IL-1β levels were determined in experimental rats.RESULTS In the 4-week of administration of Fufang Xuanju capsule,increased weight gain of the model rats was observed with lessened swelling of the joints（ P 〈0. 05 or P〈 0. 01）,which resulted in a lower serum TNF-α and IL-1β in the model rats（ P 〈0.01）. CONCLUSION Decoction of Fufang Xuanju capsule can treat the joint impairment of immunologic arthritis rats and the therapeutic mechanism may be relevant to reducing the content of TNF-α and IL-1β.

关 键 词：复方玄驹胶囊 免疫性关节炎 肿瘤坏死因子Α 白细胞介素-1Β 

分 类 号：R96[医药卫生—药理学]