急性戊型肝炎重叠慢性乙型肝炎感染的实验室特性分析  

Laboratory characteristics analysis of overlap Infection between acute hepatitis E and chronic hepatitis B

作　　者：李忻[1] 金梅[1] 刘玲[1] 陆桃红[1] 

机构地区：[1]江苏省泰州市人民医院检验科,江苏泰州225300

出　　处：《医学检验与临床》2015年第2期15-17,3,共4页Medical Laboratory Science and Clinics

摘　　要：目的：研究HEV重叠慢性乙型肝炎感染患者的临床、实验室特征及分析戊型肝炎病毒感染对慢性乙型肝炎患者肝纤维化的影响。方法：随机选取单纯HBV感染患者和HBV重叠HEV感染患者各40例，对他们的临床及实验室检查资料进行分析，研究HEV感染对慢性乙型肝炎患者临床及实验室指标的影响。结果：（1）两组患者HBeAg 、HbeAb和HBV-DNA阳性率比较,差异无统计学意义（P〉0.05）（2）重叠组重型肝炎率及自发性腹膜炎率均高于乙型肝炎组，差异有统计学意义（重型肝炎率：χ^2=10.476，P〈0.001；自发性腹膜炎率χ^2=5.878，P=0.015）。而死亡率两组比较未见统计学意义（χ^2=0.263，P=0.608）（3）两组患者血清总胆红质、丙氨酸氨基转移酶、天冬氨酸氨基转移酶比较,差异有统计学意义（4）两组患者肝纤维化指标（层粘连蛋白、Ⅲ型前胶原氨基端肽、Ⅳ型胶原及血清透明质酸）差异均有统计学意义。结论：慢性乙型肝炎重叠戊型肝炎感染可以加重患者的症状和并发症，造成严重的肝功能损伤及加重患者的肝纤维化。Objective：To study the clinical and laboratory characteristics of patients with overlap infection between Acute Hepatitis E and Chronic Hepatitis B and analyse the infection of Hepatitis E virus on the liver fibrosis of Chronic HepatitisB. Methods：Select 40 patients with HBV infection randomly and 40 patients with HBV overlapping HEV infection, analyze their clinical and laboratory data and study how HEV infection on patients with Chronic Hepatitis B affects their clinical and laboratory indexes.Results：（1） After comparison of their positive rate of both groups of patients with HBeAg, HbeAb and HBV DNA , there was no statistically significant difference （P〉0. 05）. （2） Morbidity rates of severe overlapping hepatitis and spontaneous peritonitis are higher than those of Hepatitis B group, their difference was statistically significant （rate of severe hepatitis： chi square = 10.476, P〈0.001;spontaneous peritonitis rates chi-square=5.878, P=0.015）. And mortality rates in both groups are of no statistical significance （chi-square=0.263,P=0.263）. （3） After comparison of two groups of patients with serum total bile red mass, alanine aminotransferase, aspartate aminotransferase, their differences are statistically significant. （4） After comparison of two groups of patients with liver fibrosis indexes （laminin, type Ⅲ collagen peptide amino end, before the serum hyaluronic acid and collagen type Ⅳ ）, their differences are statistically significant. Conclusions：Chronic Hepatitis B overlapping Hepatitis E can aggravate the patient＇s symptoms and complications, causing severe liver function damage and increasing hepatic fibrosis progression.

关 键 词：肝炎病毒 乙型 戊型 重叠感染 

分 类 号：R512.62[医药卫生—内科学]