缺氧诱导因子-1a血清水平与冠状动脉钙化的相关性及临床诊断价值  被引量:3

Clinical diagnosis value and the relationship between hypoxia inducible factor-1a serum levels and coronary artery calcification

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作  者:曾庆娜[1] 黄山[2] 许健[2] 冯勤颖[2] 张春阳[1] 陈洁[2] 田禾[2] 刘志琴[3] 王荣品[4] 

机构地区:[1]贵阳医学院医学检验学院,贵州贵阳550004 [2]贵州省人民医院临床检验中心,贵州贵阳550002 [3]贵州省人民医院心内科,贵州贵阳550002 [4]贵州省人民医院放射科,贵州贵阳550002

出  处:《贵州医药》2015年第3期207-209,共3页Guizhou Medical Journal

基  金:贵州省省长资金临床应用课题专项研究项目[黔省专合字(2012)117号];贵州省卫生厅科学技术基金项目(gzwkj2012-1-062)

摘  要:目的探讨HIF-1a血清水平与冠状动脉钙化的关系及临床诊断价值。方法采用ELISA法检测经双源CT检查诊断为无钙化积分和有不同钙化积分的冠心病患者血清中HIF-1a水平,并进行统计分析,绘制其ROC曲线分析其诊断性能。结果 HIF-1a在对照组与不同钙化积分疾病组之间、以及对照组与疾病组之间其血清浓度水平差异显著,疾病组中HIF-1a含量明显高于对照组;钙化积分与HIF-1a呈正相关(P<0.05);ROC曲线显示HIF-1a其曲线下面积为0.826,诊断阈值为56.53pg/mL,诊断敏感度为73.30%,特异性为73.50%,Youden指数为0.517。结论 HIF-1a在对照组和疾病组中表达不同,与钙化积分呈正相关,对冠心病诊断价值明显,对临床预防和早期诊断冠心病起到了作用。Objective To investigate the clinical diagnosis value of serum HIF‐1a level and the relationship be‐tween coronary artery calcification .Method By the test of dual source CT inspection diagnosis for non calcification score and serum HIF‐1a level in patients with coronary heart disease in different calcification score by ELISA meth‐od ,and statistical analysis ,to analyze the diagnostic performance of the ROC curve drawing .Result HIF‐1a between control group and different calcification diseases group ,and between the control group and the group of diseases whose serum concentration level significantly ,the content of HIF‐1a in disease group were significantly higher than the control group .Calcification score was positively correlated with HIF‐1a(P〈0 .05) .ROC curves show that HIF‐1a area under the curve was 0 .826 ,diagnostic threshold was 56 .53 pg/mL ,the diagnostic sensitivity was 73 .30% , specificity was 73 .50% ,Youden index was 0 .517 .Conclusion HIF‐1a expression in the control group and disease group ,Calcification was positively associated with an obvious coronary heart disease diagnostic value ,for the clinical prevention and early diagnosis of coronary heart disease has played a role in .

关 键 词:缺氧诱导因子-1a 冠心病 冠状动脉钙化 诊断价值 

分 类 号:R543.3[医药卫生—心血管疾病]

 

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