丹参总酚酸鼻用原位凝胶的制备工艺研究  

Optimization for preparation technology of Salvia total phenolic acids in situ nasal gel

作　　者：范少敏[1] 史亚军[1] 周玉凯[1] 王卉[1] 邓辉[1] 张小飞[1] 

机构地区：[1]陕西中医学院药学院,咸阳712046

出　　处：《陕西中医》2015年第6期730-731,738,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省科技厅科技攻关计划项目(2013K12-07-03);陕西省重点科技创新团队项目(2013KCT-26);陕西中医学院创新基金项目(14XJZR01)

摘　　要：目的:优化丹参总酚酸提取物鼻用原位凝胶的制备工艺。方法:采用单因素结合正交试验法,以胶凝温度为评价指标,对处方中泊洛沙姆P407、泊洛沙姆P188、PEG6000的用量进行考察。结果:最终确定鼻用凝胶的制备工艺为:取0.84g药物,加入60mL三乙醇胺溶液(0.1%)搅拌使溶解,加入16g泊洛沙姆P407、1g泊洛沙姆P188、1g PEG6000,于冰浴条件(4℃)下,磁力搅拌使其分散均匀,加蒸馏水调整总量至100mL,然后置于4℃冰箱中保存24h,即得澄清溶液。结论:优选的工艺适用于丹参总酚酸提取物鼻用原位凝胶的制备。Objective：To optimize the preparation technology of salvia total phenolic acids in situ nasal gel .Meth‐ods：Taking the gelation temperature as index ,the amount of poloxamer407 ,poloxamer188 and polyethylene glycol 6000 were optimized by single factor and orthogonal design .Results ：The optimized preparation as follows ：salvia total phenolic acids（0 .84 g） was dissolved in 0 .1% triethylamine solution ,P407 （16 g） ,P188 （1 g） ,PEG 6000 （1 g） and distilled water were added to reach 100 mL .The mixture was uniformly dispersed in ice bath （4℃） under the magnetic stirring and then was stored at 4℃ in refrigerator for 24 h .The fully dissolved and clear solution was obtained .Conclusion：The optimized preparation technology of salvia total phenolic acids in situ nasal gel is stable and suitable .

关 键 词：凝胶剂 正交试验 @丹参总酚酸 

分 类 号：R282[医药卫生—中药学]