左卡尼汀对维持性血液透析患者慢性心力衰竭的疗效观察  

Observation of curative effect by levocarnitine for chronic cardiac failure in maintenance hemodialysis patients

作　　者：高增辉[1] 李海霞[1] 丁惠芳[1] 

机构地区：[1]郑州人民医院血液透析室,450000

出　　处：《中国实用医药》2015年第15期42-43,共2页China Practical Medicine

摘　　要：目的观察左卡尼汀治疗维持性血液透析患者并慢性心力衰竭的疗效。方法 46例维持性血液透析合并慢性心力衰竭患者随机分为对照组和治疗组,每组23例,治疗组在每次透析结束前,将左卡尼汀1.0 g稀释于10 ml生理盐水中缓慢推注;对照组于透析结束前推注20 ml生理盐水。比较两组治疗前后临床疗效及心功能指标的变化。结果治疗组临床疗效较对照组明显,差异有统计学意义(P<0.05),治疗后治疗组心功能指标改善较对照组更明显,差异有统计学意义(P<0.05)。结论左卡尼汀对维持性血液透析合并慢性心力衰竭患者疗效确切,对患者心功能有明显的改善。Objective To observe the curative effect by levocarnitine for chronic cardiac failure in maintenance hemodialysis patients. Methods A total of 46 maintenance hemodialysis patients complicated with chronic cardiac failure were randomly divided into control group and treatment group, with 23 cases in each group. The treatment group received slow injection of 1.0 g levocarnitine diluted in 10 ml normal saline before the end of each hemodialysis. The control group received 20 ml normal saline through injection at the same time. Clinical effects and cardiac function indications before and after treatment were compared between the two groups. Results The treatment group had obviously better clinical effect than the control group and the difference had statistical significance （P〈0.05）. The treatment group also had more obvious improvement in cardiac function indications than the control group after treatment, and their difference had statistical significance （P〈0.05）. Conclusion Levocarnitine provides precise effect for maintenance hemodialysis patients complicated with chronic cardiac failure, along with obvious improvement in cardiac function.

关 键 词：血液透析 慢性心力衰竭 左卡尼汀 

分 类 号：R459.5[医药卫生—治疗学]