急性ST段抬高型心肌梗死患者血清结缔组织生长因子表达的研究  

Expression of Connective Tissue Growth Factor in Patients With ST-segment Elevation Myocardial Infarction

作　　者：李勇[1] 李莉[1] 祁春梅[1] 刁军[1] 武维恒[1] 冯建启[1] 

机构地区：[1]徐州医学院第二附属医院心内科,江苏省徐州市221006

出　　处：《中国循环杂志》2015年第6期540-542,共3页Chinese Circulation Journal

摘　　要：目的：检测急性ST段抬高型心肌梗死患者血清中结缔组织生长因子（CTGF）表达的变化及其与肌酸激酶同工酶（CK-MB）酶活性峰值的相关性。方法：选择2013-07至2014-06入院的急性ST段抬高型心肌梗死患者（心肌梗死组）及不稳定性心绞痛患者（心绞痛组）各50例。酶联免疫吸附试验（ELISA）分别检测ST段抬高型心肌梗死组发病1、2、7、14天及心绞痛组入院后24 h内血清CTGF蛋白浓度，免疫抑制法检测心肌梗死组患者CK-MB酶活性峰值。结果：心绞痛组血清CTGF蛋白浓度为（10.34±2.00）ng/ml；心肌梗死组患者入院后1、2、7、14天血清CTGF蛋白浓度分别为（16.76±3.17）ng/ml、（29.87±4.90）ng/ml、（45.02±8.35）ng/ml、（31.61±4.40）ng/ml；心肌梗死组患者发病后各时间段血清CTGF蛋白浓度较心绞痛组患者高，且差异有统计学意义（P〈0.01）；心肌梗死组患者发病后血清CTGF蛋白浓度1~7天逐渐升高，后逐渐下降，差异有统计学意义（P〈0.01）；7天时血清CTGF蛋白浓度与CK-MB酶活性峰值呈正相关关系（r=0.859，P=0.000）。结论：本研究中急性ST段抬高型心肌梗死患者CTGF表达上调，可能与心肌梗死后心肌纤维化相关；CTGF浓度与心肌梗死面积存在相关性，对于预测心肌梗死面积有一定的临床意义。Objective： To detect the changes of serum level of connective tissue growth factor （CTGF） in patients with ST-segment elevation myocardial infarction （STEMI） and to study the correlation between CTGF level and the maximal activity of creatine kinase-MB （CK-MB）. Methods： Our research included 2 groups of patients： STEMI group and unstable angina （UA） group. All patients were treated in our hospital from 2013-07 to 2014-06,n=50 in each group. In STEMI group, the serum levels of CTGF were examined by ELISA at 24h, 2, 7, 14 days of onset, and in UA group, CTGF level was examined at 24h of onset. The CK-MB activity levels were measured in STEMI group at the same time points by immunosuppression method. Results： The serum level of CTGF in UA patients at 24 h of onset was （10.34 ± 2.00） ng/mL, and in STEMI patients were （16.76 ± 3.17） ng/mL at 24h, （29.87 ± 4.90） ng/mL at 2d, （45.02 ± 8.35） ng/mL at 7d and （31.61 ± 4.40） at 14d. The CTGF levels in STEMI group at different time points were all higher than UA group at 24h of onset,P〈0.01. In STEMI group, the CTGF levels were increasing from 24h to 7d, then decreasing at 14d, allP〈0.01. In STEMI group, the highest protein concentration of CTGF was positively related to the maximal activity of CK-MB at 7 days of onset （r=0.859,P=0.000）. Conclusion： CTGF expression has been up-regulated in STEMI patients which might be related to myocardial ifbrosis. The protein level of CTGF is related to MI size, it shows certain predictive value in relevant patients.

关 键 词：结缔组织生长因子 心肌梗死 

分 类 号：R54[医药卫生—心血管疾病]