麝香正骨酊联合活血止痛散治疗急性外伤肿痛的临床观察  

Clinical Observation of Shexiang Zhenggu Tincture Combined with Huoxue Zhitong Powder in the Treatment of Acute Traumatic Swelling and Pain

作　　者：孙小东[1] 何秦[1] 宋敏[2] 

机构地区：[1]达州市中心医院,四川达州635000 [2]资阳市第一人民医院,四川资阳641300

出　　处：《中国药房》2015年第18期2486-2488,共3页China Pharmacy

摘　　要：目的:观察麝香正骨酊联合活血止痛散治疗急性外伤肿痛的临床疗效和安全性。方法:160例急性外伤肿痛患者随机均分为A组和B组。A组患者给予麝香正骨酊外用涂抹伤处,tid;B组患者在A组治疗基础上加用活血止痛散1.5 g,口服,tid。两组患者均以7 d为1个疗程,连续治疗2个疗程。观察两组患者的临床疗效,治疗前和治疗7、14 d后疼痛视觉模拟评分法(VAS)评分、肿胀缓解评分及不良反应发生情况。结果:治疗7 d后,A组患者总有效率显著低于B组,差异有统计学意义(P<0.05);治疗14 d后两组患者总有效率比较差异无统计学意义(P>0.05)。治疗7、14 d后,两组患者VAS评分、肿胀缓解评分均显著低于同组治疗前,治疗14 d后两组显著低于同组治疗7 d后,且治疗7 d后B组显著低于A组,差异均有统计学意义(P<0.05);治疗14 d后,两组患者VAS评分、肿胀缓解评分比较,差异均无统计学意义(P>0.05)。两组患者均未见明显不良反应发生。结论:麝香正骨酊联合活血止痛散相比单用麝香正骨酊治疗急性外伤肿痛起效更快,可在更短时间内缓解疼痛、肿胀情况,且安全性相当。OBJECTIVE：To observe the efficacy and safety of Shexiang zhenggu tincture combined with Huoxue zhitong powder in the treatment of acute traumatic swelling and pain. METHODS：Totally 160 patients with acute traumatic swelling and pain were randomly divided into group A and group B. Patients in group A were given Shexiangzhenggu tincture for external use,3times a day;patients in group B were orally added one bag of Huoxue zhitong powder,3 times a day,based on the treatment of control group. 7 d was course and it lasted 2 courses. The clinical efficacy,the scores of visual analogue pain score（VAS） and swelling remission before and after 7 and 14 d treatment and the incidence of ADR were observed. RESULTS：After 7 d treatment,the total effective rate in group A was significantly higher than group B,with significant difference（P〈0.05）;after 14 d treatment,there was no significant difference in the total effective rate between 2 groups（P〉0.05）. After 7 and 14 d,the scores of VAS and swelling remission were significantly lower than before;14 d treatment was lower than 7 d treatment,and group B was significantly lower than group A after 7 d treatment,with significant differences（P〈0.05）;there were no significant differences among the scores of VAS and swelling remission in 2 groups after 14 d treatment（P〉0.05）. No obvious ADR was found in 2groups during treatment. CONCLUSIONS：Shexiang zhenggu tincture combined with Huoxue zhitong powder has better efficacy,can relieve the pain and swelling faster,with similar safety.

关 键 词：麝香正骨酊 活血止痛散 急性外伤肿痛 疗效 安全性 

分 类 号：R68[医药卫生—骨科学]