塑料输液瓶和输液器对地西泮的吸附性考察  

Adsorbability Study of Plastic Transfusion Bottle and Infusion Set to Diazepam

作　　者：夏清荣[1] 梁俊[1] 曹银[1] 

机构地区：[1]合肥市第四人民医院药剂科,合肥230022

出　　处：《中国药房》2015年第18期2564-2566,共3页China Pharmacy

摘　　要：目的：考察塑料输液瓶和输液器对地西泮的吸附性。方法：以玻璃瓶装的5%葡萄糖注射液为对照,采用高效液相色谱（HPLC）法测定地西泮加入塑料瓶装的5%葡萄糖注射液后放置不同时间的质量浓度变化;并连接一次性塑料输液器模拟静滴状态,于不同时间收集流出液体测定其中地西泮的质量浓度变化。结果：玻璃瓶组地西泮质量浓度高于塑料瓶组,两组溶液经过输液器15~20 min时吸附性最强,玻璃瓶组流出液体质量浓度约为初始浓度的80%,塑料瓶组约为67%;随着时间的延长,到60min时吸附渐渐达到饱和状态,质量浓度回升;到80 min时玻璃瓶组流出液体质量浓度恢复到初始浓度的95%,塑料瓶组约为初始浓度的75%。结论：塑料输液瓶和输液器对地西泮均有较强的吸附作用,建议在使用塑料瓶装的5%葡萄糖注射液作为溶剂静脉滴注地西泮时,应增加25%~33%的用量。OBJECTIVE：To study the adsorbability of plastic transfusion bottle and infusion set to diazepam. METHODS：With the reference of plastic-bottled 5% glucose injection,HPLC was used to determine the changes of mass concentration of diazepam adding into plastic-bottled 5% glucose injection at different time;disposable plastic infusion set was connected to simulate intravenous infusion and determine the changes of mass concentration of diazepam in the liquid effluent at different time. RESULTS：The mass concentration of diazepam in glass infusion bottles group was higher than in plastic transfusion bottles group. The adsorbabilities of solutions showed the strongest at the time of 15-20 min. The mass concentration of the effluent liquid from the glass bottle group was about 80% of the original concentration and plastic bottle group was about 67%. As the time went on,the adsorbability was gradually saturated at 60 min and the concentration rose again;the mass concentration of the effluent liquid from the glass bottle group returned to 95% of the original concentration at 80 min and the plastic bottle group was about 75% of the original concentration. CONCLUSIONS：Both plastic infusion bottle and infusion set have strong adsorbability to diazepam. It is suggested that the dosage of diazepam should be increased by 25% to 33% while plastic-bottled 5% glucose injection is used as solvent for intravenous drip.

关 键 词：塑料输液瓶 一次性塑料输液器 地西泮 吸附性 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学]