高血压对大脑年龄估值差的影响  

Advanced Brain AGE in Elder Adults with Hypertension

作　　者：林岚[1] 张柏雯 付振荣[1] 靳聪[1] 吴水才[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《中国医疗设备》2015年第6期7-11,共5页China Medical Devices

基　　金：北京市自然科学基金(7143171)资助

摘　　要：高血压病人在未发生临床脑卒中之前,脑形态、功能以及脑网络已经产生了一定程度的损害,这些无症状的损害可引起认知能力的衰退。随着我国人口老龄化的加速,高血压患者的基数及其在人口中的比例也不断扩大,研究高血压(HTN)对人脑认知的影响是健康认知老化中的一个极其重要的问题。大脑年龄估值差(Brain AGE)被用于计算脑年龄与实际年龄的差别。118个对象(41个高血压患者)的磁共振图像首先通过图论分析,随后采用与年龄相关的脑网络拓扑特征来预测脑年龄。HTN的脑年龄比实际年龄高(4.1±3.1)岁,而健康对照组的脑年龄与实际年龄基本相符。Brain AGE可以作为一种临床生物标志物用来检测与HTN相关的脑异常老化模式。Long before patients in clinical stroke, hypertension （HTN） has caused a certain degree of damage on brain morphology, cognitive function and network. These asymptomatic damages can cause cognitive decline in function. With the acceleration of China’s aging population, cardinality and the proportion of the patients with HTN continues to expand. And the impact of HTN on the human brain becomes an important issue of healthy cognitive aging. The “Brain Age Gap Estimation” （BrainAGE） score was used to calculate the difference between the estimated brain age and chronological age. Analysis of 118 subjects （41 with HTN）’s MRI were ifrstly made using the graph theory. Then the brain age was estimated based on topological properties related to the age. The estimated brain age of HTN subjects in HTN Group was （4.1 ± 3.1） years greater than their chronological age, whereas the BrainAGE in Control Group was close to the chronological age. In summary, the BrainAGE may serve as a clinically relevant bio-marker to reveal the abnormal brain aging associated with HTN.

关 键 词：磁共振成像 脑连接组 多尺度分割模板 弥散张量成像 脑网络特征 高血压 

分 类 号：R197.39[医药卫生—卫生事业管理]