T1 mapping定量技术评价左室不同区域心肌初始T1值的初步研究  

A Preliminary Study of the Quantitative T1 Mapping Technique in Evaluation of the Native Left Ventricular Myocardial T1 Value in Different Segments

作　　者：刘明熙[1] 张挽时[1] 张子衡 周振宇[1] 解立志[1] 孟利民[1] 徐先荣[1] 田建伟[1] 龚万沣 祝红线[1] 刘洁[1] 

机构地区：[1]空军总医院CTMR科室,北京100142 [2]GE医疗北京磁共振研究中心,北京100176

出　　处：《中国医疗设备》2015年第6期33-38,6,共7页China Medical Devices

摘　　要：目的探讨3.0T心脏磁共振(CMR)检查中基于改进的Look-Locker稳态自由进动饱和恢复序列(MLLSR)的T1 mapping定量技术的可行性和可重复性,并评价左室不同区域心肌初始T1值以供参考。方法选取30例健康志愿者,分别行心脏Cine电影、T2WI序列、T1 mapping序列扫描,测定感兴趣区初始T1值,应用独立样本t检验和方差分析方法统计分析心肌17节段、不同冠状动脉供血区、年龄和性别下的差异性。结果健康志愿者17节段心肌初始T1值不全相等(P<0.01),心肌平均初始T1值和血池平均初始T1值如下:基底部,(717.6±100.6)ms,(1208.9±224.2)ms;中间部,(773.9±101.2)ms,(1281.2±251.7)ms;心尖部,(955.4±191.1)ms,(1829.6±584.8)ms。心尖部心肌和血池初始T1值高于基底部和中间部(P<0.01)。初始T1值在不同冠状动脉供血区间有统计学差异(F=47.862,P<0.01)。结论CMR MLLSR T1 mapping定量技术在心脏成像中具有较好的可行性和可重复性,其在评价左室不同区域心肌初始T1值间存在节段性差异。Objectives To investigate the clinical feasibility and repeatability of a MLLSR [Modified Look-Locker FIESTA （Fast Imaging Employing Steady State Acquisition） Imaging with Saturation Recovery]-based quantitative T1 mapping technique in 3.0T CMR （Cardiac Magnetic Resonance） to evaluate the left ventricular myocardial T1native values in different segments.Methods Altogether 30 healthy volunteers were selected and scanned by CMR on the sequence of Cine imaging, T2WI and T1 mapping so as to perform quantitative measurement of ROI （Region of Interest） T1native values. Then, the independent-samplesT test and ANOVA （Analysis of Variance） were deployed to analyze the difference of the T1native values in 17 segments of myocardium, different coronary arterial blood supply areas, age and gender.Results There were differences of the T1native values between some segmental myocardia（P〈0.01）. The mean myocardial T1native and T1native of blood pool were：（717.6±100.6） ms and （1208.9±224.2） ms at the base; （773.9±101.2） ms and （1281.2±251.7） ms in the middle; （955.4±191.1） ms and （1829.6±584.8） ms at the apex, respectively. Apical T1native values of myocardium and blood pool were higher than the basal and the middle （P〈0.01）. Also, statistically significant differences （F=47.862,P〈0.01） existed in T1native values of different coronary arterial blood supply areas.Conclusion The CMR MLLSR T1 mapping technique had demonstrated its excellent feasibility and repeatability, which revealed segmented variations in evaluation of left ventricular myocardial T1native values.

关 键 词：心脏磁共振 T1 MAPPING 改进的Look—Locker稳态自由进动饱和恢复 健康志愿者 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]