盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的效果观察  

Effect of penehyclidine hydrochloride injection combined with atropine on acute organophosphate poisoning

作　　者：钟鸿波 戴培源 唐元旭 赵思寅 陶云坤[2] 陈斌[2] 周俊[2] 

机构地区：[1]云南省玉溪市急救中心急救科,653100 [2]玉溪市人民医院急诊科

出　　处：《中国实用医刊》2015年第13期57-59,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的临床效果。方法选取2012年2月至2014年2月诊治的急性有机中毒患者158例，随机分为两组，每组79例。对照组在常规基础上采用阿托品治疗，研究组在常规基础上采用盐酸戊乙奎醚注射液治疗，比较两组中毒患者各项疗效性指标、用药不良反应及用药过量、治愈和死亡发生情况。结果研究组中毒患者疗效均优于对照组，且部分用药不良发生情况优于对照组，差异均有统计学意义（P〈0．05）；研究组中毒患者用药过量及治愈发生率分别为11．39％、93．67％，均优于对照组（41．77％、79．75％），差异均有统计学意义（P〈0．05），病死率（1．27％）与对照组（3．80％）比较差异未见统计学意义（P〉0．05）。结论盐酸戊乙奎醚注射液联合阿托品治疗急有机磷中毒患者的临床效果显著，且无严重用药不良反应，病死率低。Objective To observe the effect of penehyclidine hydrochloride injection combined atropine acute or- ganophosphate poisoning. Methods From February 2012 to February 2014,158 cases of patients with acute organophos- phorus poisoning admitted in hospital were randomly selected as research subject. All the cases were divided into two groups with a double-blind method. The 79 cases of poisoning in control group were treated with atropine therapy on regular basis, and 79 cases in the study group were given hydrochloric acid in penehyclidine injection therapy on this basis. The efficacy index, adverse drug reactions and medication overdose, cure and death occurrence of the two groups were compared. Re- suits The efficacy index in study group was significantly better than that in the control group and the incidence of adverse drug section was lower, the differences were both statistically significant（ P 〈 0. 05 ） ; the incidence of overdose and poison- ing cured in study group was 11.39 % and 93.67%, which were significantly higher than that in the control group （41.77% and 79.75% ） ; the differences were statistically significant（ P 〈 0. 05 ）. The mortality rates of study group and control group were 1.27% and 3.80% , which had no significant difference （ P 〉 0. 05 ）. Conclusions Penehyclidine hydrochloride injection combined with atropine in treatment of acute organophosphate poisoning has significant clinical effect, and no serious adverse drug reactions, with low mortality rate.

关 键 词：盐酸戊乙奎醚 阿托品 急性 有机磷中毒 疗效 

分 类 号：R996[医药卫生—毒理学]