抗环瓜氨酸肽抗体定量检测在类风湿性关节炎诊断中的临床应用  

The application of ring citrulline peptide antibody quantitative detection in the diagnosis of rheumatoid arthritis

作　　者：邹长进[1] 许海兵[1] 郑迎春[1] 

机构地区：[1]枝江市人民医院,湖北枝江443200

出　　处：《中国卫生检验杂志》2015年第11期1786-1787,1790,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨抗环瓜氨酸肽抗体(抗CCP)定量检测在类风湿性关节炎(RA)中的应用价值。方法临床确诊类风湿性关节炎患者150例(RA组),其他自身免疫性疾病患者135例(非RA组),健康体检者120例(对照组),对其进行抗CCP、类风湿因子(RF)、超敏C反应蛋白(hs-CRP)的定量检测,比较其相关性。结果 RA组抗CCP、RF含量明显高于非RA组和对照组,差异有统计学意义(P<0.01),hs-CRP含量与非RA组差异无统计学意义(P>0.05),但均与对照组差异有统计学意义(P<0.01)。非RA组抗CCP、RF含量与对照组差异无统计学意义(P>0.05)。RA组抗CCP、RF、hs-CRP含量明显与RA患者关节受损程度呈正相关(r分别为0.741、0.654、0.432,P<0.01)。以抗CCP>40 U/ml、RF>20 U/ml为阳性标准,比较其对RA患者诊断的敏感度和特异度,抗CCP敏感度略低而特异度较高。结论抗CCP定量检测因其操作简单、特异性较高,对RA的临床诊断具有较大价值。Objective To discuss the application value of ring citrulline peptide antibody（CCP） resistance quantitative detec- tion in the diagnosis of rheumatoid arthritis（RA）. Methods The clinical diagnosed 150 cases of patients with rheumatoid ar- thritis（ RA group）, and 135 cases of patients with other autoimmune diseases（ non- RA group） and 120 cases of healthy con- trois （ control group） were selected, uneffection anti - CCP, rheumatoid factor （ RF）, hypersensitive c - reactive protein （ hs - CRP） quantitative detection were performed, and the correlation among them was compared. Results Anti - CCP, RF content in RA group was obviously higher than that of the non - RA group and the control group, and the difference had statistical signif- icance（P 〈0.01 ）, and the difference on the hs -CRP levels between RA group and the non -RA group was not statistically significant （ P 〉 0. 05 ）, but the differences of both of them were all statistically significant compared to the healthy control group （ P 〈 0.01 ）. The difference of anti - CCP and RF content between the non - RA group and the control group was not statistically significant（ P 〉0.05 ）. The CCP, RF, and hs - CRP content of RA group were significantly positively correlated （r was 0. 741, 0. 654 and 0. 432, P 〈0. 01 ）. Regarding anti- CCP 〉 40 U/m1, RF 〉 20 U/ml as positive standard, to compare the sensitivity and specificity of diagnosis of RA patients, anti - CCP had slightly lower sensitivity and higher specificity. Conclu- sion Anti - CCP quantitative detection, because of its simple operation and higher specificity, has a larger value in the clinical diagnosis of RA.

关 键 词：抗环瓜氨酸肽抗体 类风湿性关节炎 类风湿因子 超敏C反应蛋白 

分 类 号：R593.22[医药卫生—内科学]