Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification  

作　　者：Jianlei Shen Jing Su Juan Yan Bin Zhao Dongfang Wang Siyi Wang Kun Li Mengmeng Liu Yao He Sanjay Mathur Chunhai Fan Shiping Song 

机构地区：[1]Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China [2]Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key, Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China [3]Institute of Inorganic Chemistry, University of Cologne, D-50939 Cologne, Germany

出　　处：《Nano Research》2015年第3期731-742,共12页纳米研究（英文版）

基　　金：We thank the National Basic Research Program of China （973 program） （Nos. 2013CB932802 and 2012CB932600）,Alexander von Humboldt Foundation, and the National Natural Science Foundation of China （Nos. 91127037 and 91123037） for financial support.

摘　　要：Uniform silver-containing metal nanostructures with well-defined nanogaps hold great promise for ultrasensitive surface-enhanced Raman scattering （SERS） analyses. Nevertheless, the direct synthesis of such nanostructures with strong and stable SERS signals remains extremely challenging. Here, we report a DNA-mediated approach for the direct synthesis of gold-silver nano-mushrooms with interior nanogaps. The SERS intensities of these nano-mushrooms were critically dependent on the area of the nanogap between the gold head and the silver cap. We found that the formation of nanogaps was finely tunable by controlling the surface density of 6-carboxy-X-rhodamine （ROX） labeled single-stranded DNA （ssDNA） on the gold nanoparticles. We obtained nano-mushrooms in high yield with a high SERS signal enhancement factor of -1.0×109, much higher than that for Au-Ag nanostructures without nanogaps. Measurements for single nano- mushrooms show that these structures have both sensitive and reproducible SERS signals.有为散布的提高表面的拉曼(重量的单位) 分析的 ultrasensitive 的明确的 nanogaps 抓住伟人诺言的一致包含银的金属 nanostructures。不过，有强壮、稳定的重量的单位的如此的 nanostructures 的直接合成表明极其质问的遗体。这里，我们与内部 nanogaps 为金银的 nano 蘑菇的直接合成报导一条调停 DNA 的途径。这些 nano 蘑菇的重量的单位紧张极其依赖于在金头和银帽子之间的 nanogap 的区域。我们发现 nanogaps 的形成由控制在金 nanoparticles 上标记搁浅单人赛的 DNA (ssDNA ) 的 6-carboxy-X-rhodamine (ROX ) 的表面密度是细微地悦耳的。我们与 1.0 的一个高重量的单位信号改进因素在高产量获得了 nano 蘑菇我们作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗？？

关 键 词：surface-enhanced Ramanscattering biometallic nanostructure nano-mushroom NANOGAP gold nanoparticle 

分 类 号：TB383[一般工业技术—材料科学与工程] Q523[生物学—生物化学]