非药物干预措施对体检人群轻度血脂、血尿酸异常的作用  

Effect of non-drug management upon mild abnormalities of blood lipid and uric acid levels in health check-up people

作　　者：王振捷[1] 魏凡[1] 李冬晶[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院健康医学部,100730

出　　处：《北京医学》2015年第6期558-560,共3页Beijing Medical Journal

摘　　要：目的探讨经非药物干预即加强健康宣教、饮食运动管理后,轻度代谢指标异常体检者的血脂、血尿酸变化趋势。方法选择2014年1-6月在北京协和医院体检中心进行健康体检的年龄〉40岁的轻度血脂、血尿酸异常的中老年人,自愿选择非药物干预方法改善血脂、血尿酸等代谢指标,6个月后进行第2次体检。比较2次体检高尿酸血症、高甘油三酯血症、高胆固醇血症、脂肪肝的检出率,对比血尿酸、TG、LDL-C、HDL-C水平。结果 124例患者纳入本研究,男104例,女20例;平均年龄（59.23±5.48）岁;平均干预、随访时间（201.1±13.3）d。第2次体检时,男性的高尿酸血症检出率较第1次体检时明显降低[29.8%（31/104）vs.42.3%（44/104）,P〈0.05];2次高TG、高TC、高LDL-C、低HDL-C、脂肪肝及女性高尿酸血症检出率的差异无统计学意义（P均〉0.05）。第2次指标与第1次比较,血TG[（1.33±0.74）mmol/L vs.（1.53±0.80）mmol/L]及男性的血尿酸水平[（382.92±64.09）μmol/L vs.（404.19±71.40）μmol/L]均显著下降,差异有统计学意义（P均〈0.05）;而血TC、LDL-C、HDL-C水平无明显改善（P均〉0.05）。结论健康宣教、健康意识的提升以及科学饮食等非药物干预措施可改善轻度TG异常,及男性轻度血尿酸异常,但对LDL-C等血脂水平的改善作用有限,可能需要长期非药物干预,并根据指南要求给予他汀类降脂药物治疗。Objective To investigate the changes of mild abnormalities of blood uric acid and blood lipid levels in health check-up people after non-drug intervention such as implement of health education, management of diet and exercise. Methods The health check-up people were choosed in PUMC hospital from January to June in 2014, who were more than 40 years old, who had mild abnormalities of blood uric acid and blood lipid levels, and preferred to non-drug intervention. A second check-up was arranged after 6 months. The incidences of hyperuricemia, hyperlipidemias, fatty liver, the blood levels of uric acid and TG, LDL-C, HDL-C were compared. Results A total of 124 people were involved, 104 male and 20 female, average age was （59.23±5.48） years old, average period of intervention was（201.1± 13.3） d. In the second time of health check-up, the incidence of hyperuricemia was lower in male than that of 6 months before [29.8%（31/ 104） vs. 42.3%（44/104）, P 〈 0.05]; while the incidence of hyperuricemia in female, high TG, high TC, high LDL-C, low HDL-C, fatty liver were not changed（P all 〉0.05）. The levels of blood TG [ （1.33±0.74）mmol/L vs. （1.53±0.80）mmol/L] and blood uric acid [（382.92±64.09）μmol/L vs. （404.19±71.40）μmol/L] were both lower （P 〈0.05）, while the levels of TC, LDL-C, HDL-C had no significant changes （P 〉 0.05）. Conclusion Non-drug management, such as health education, health consciousness promotion and scientific diet, can improve mild abnormalities of TG, and uric acid levels in male. But only food-control is not easy to decrease the levels of LDL-C. Maybe it needs a long period of non-drug management. Or statin according to guideline is useful.

关 键 词：高脂血症 高尿酸血症 健康管理 

分 类 号：R194.3[医药卫生—卫生事业管理]