N-乙酰化转移酶2基因多态性与抗结核药物致肝损伤的关系研究  

A study on the relationship between NAT2 genetic polymorphisms and biomarkers related to anti- tuberculosis drug- induced liver injury

作　　者：林森[1] 唐少华 阎绍荣[1] 

机构地区：[1]温州医科大学附属三院检验科,浙江瑞安325200 [2]温州市中心医院检验科

出　　处：《浙江预防医学》2015年第6期564-567,共4页Zhejiang Journal of Preventive Medicine

基　　金：瑞安市科技局项目(YY2014029)

摘　　要：目的探讨N-乙酰化转移酶2(NAT2)基因多态性与抗结核药物致肝损伤相关实验室指标的相关性。方法应用焦磷酸测序法检测抗结核治疗3个月内出现肝损伤患者41例和未出现肝损伤患者88例的NAT2基因多态性,并对所有患者肝功能检测指标进行分析。结果抗结核治疗后,不同NAT2乙酰基因型结核病病例的6项肝功能指标较治疗前均有升高(P均<0.01)。抗结核治疗后,不同基因型的ALT检测值之间存在差异(P<0.05),其中快乙酰型的ALT水平明显低于慢乙酰型(P<0.05);但其他5项肝功能指标在不同基因型间的差异均无统计学意义(P>0.05)。结论 NAT2基因多态性与患者治疗后ALT水平升高存在一定相关性,应重视该指标的变化。Objective To know the relationship between NAT2 genetic polymorphisms and biomarkers related to anti -tuberculosis drug -induced liver injury （ATLI）.Methods A total of 41 pulmonary tuberculosis patients with ATLI who received treatment within three months and 88 patients without ATLI were enrolled.The NAT2 genotypes were analyzed by pyrosequencing,and the biomarkers of liver function were analyzed.Results After anti -tuberculosis treatment,six biomarkers of liver function of pulmonary tuberculosis patients with different NAT2 genotypes were significantly higher than those before treatment（P 〈0.01 ）.And there were significant differences in ALT level between different genotypes（P 〈0.05）,the ALT levels of the fast acetylation genotype were significantly lower than that of the slow acetylation genotype（P〈0.05 ）,but no significant differences were observed in the other 5 biomarkers of liver function between different genotypes（P 〉0.05）.Conclusion There is a certain relationship between NAT2 genetic polymorphisms and the elevated ALT levels among pulmonary tuberculosis patients after treatment.

关 键 词：N-乙酰化转移酶2 基因多态性 药物性肝损伤 肝功能 

分 类 号：R978.3[医药卫生—药品] R575[医药卫生—药学]