甲状腺功能与心血管疾病的关系研究  

Relationship between thyroid function and cardiovascular diseases

作　　者：刘梅[1] 周炳凤[1] 施有为[1] 徐少东[1] 孟影[1] 郑建发[1] 许晴鹤[1] 刘闵育[1] 高瑛[1] 高菲[1] 刘伟[2] 

机构地区：[1]合肥市第一人民医院集团滨湖医院心内科,安徽合肥230061 [2]合肥市第一人民医院集团滨湖医院检验科,安徽合肥230061

出　　处：《心血管康复医学杂志》2015年第3期267-270,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨甲状腺功能与心血管疾病的关系。方法:选择在住院期间测定甲状腺功能的患者980例,根据甲状腺功能分为甲状腺功能正常组(正常组,930例),亢进组(甲亢组,18例)及减退组(甲减组,32例),分析3组临床资料,比较血脂,凝血功能各指标。结果:与正常组比较,甲亢组的房颤发生率显著升高,高血压,心功能不全发生率显著降低;TC、TG、LDL-C、HDL-C水平显著降低,部分活化凝血酶原时间显著延长,P均<0.01;甲减组冠心病发生率显著升高,TG、HDL-C水平显著升高,TC、LDL-C水平显著降低,P均<0.01;与甲亢组比较,甲减组高血压、冠心病发生率显著升高,房颤发生率显著显著降低P<0.05或<0.01;TG、LDL-C、HDLC水平显著升高,TC水平显著降低P均<0.01。结论:甲状腺功能与心血管疾病有密切关系,建议甲状腺功能检查作为心血管患者的常规测定,及甲状腺功能异常者的随访指标。Objective：To explore the relationship between thyroid function and cardiovascular diseases .Methods：A total of 980 patients undergoing thyroid function examination during hospitalization were selected . According to their thyroid function ,they were divided into normal thyroid function group （normal group ,n= 930） , hyperthy-roidism group （n=18） ,and hypothyroidism group （n=32） .Clinical data were analyzed ,blood lipids and coagula-tion function indexes were examined and compared among three groups . Results：Compared with normal group ,the incidence rate of atrial fibrillation significantly rose ,incidence rate of hypertension ,cardiac insufficiency signifi-cantly reduced;levels of TC、TG、 LDL-C、 HDL-C significantly reduced ,activated partial thromboplastin time significantly extended in hyperthyroidism group , P〈0.01 all;incidence rate of coronary heart disease significantly rose ,levels of TG、HDL-C significantly rose ,levels of TC 、LDL-C significantly reduced in hypothyroidism group , P〈0.01 all;Compared with hyperthyroidism group ,the incidence rate of hypertension ,coronary heart disease sig-nificantly rose ,atrial fibrillation significantly reduced ,P〈0.05 or 〈0.01 ;levels of TG、LDL-C、HDL-C signifi-cantly rose ,TC level significantly reduced in hypothyroidism group , P〈0. 01 all .Conclusion：Thyroid function is closely related to cardiovascular diseases .so it′s suggested that thyroid function detection should be regarded as a routine examination in patients with cardiovascular diseases and a follow-up index for those with thyroid dysfunction .

关 键 词：心血管疾病 甲状腺功能亢进症 甲状腺功能减退症 危险因素 

分 类 号：R540.9[医药卫生—心血管疾病]