盐酸艾司洛尔并氨氯地平治疗高血压并主动脉夹层的疗效  

Therapeutic effect of combined therapy of esmolol hydrochloride and amlodipine on patients with hypertension complicated aortic dissection

作　　者：陈盈文[1] 吴焱贤[1] 李彩华[1] 杨友[1] 陈玉映[1] 张奕文[2] 罗德谋[3] 

机构地区：[1]佛山市顺德区第一人民医院心内科,广东佛山528300 [2]佛山市顺德区第一人民医院麻醉科,广东佛山528300 [3]广东省人民医院心血管内科

出　　处：《心血管康复医学杂志》2015年第3期300-303,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：佛山市医学类科技攻关项目(201208289)

摘　　要：目的:探讨盐酸艾司洛尔联合苯磺酸氨氯地平治疗高血压合并主动脉夹层对患者血压及心率的影响。方法:高血压合并主动脉夹层患者110例,被随机分为氨氯地平组和联合用药组(氨氯地平+艾司洛尔),各55例。结果:与治疗前相比,治疗0.5、1.5、7h后两组患者收缩压和舒张压均明显下降(P<0.01),治疗7h后,联合用药组患者收缩压显著低于氨氯地平组[(101.5±7.8)mmHg比(123.4±10.2)mmHg,P<0.01]。治疗0.5、1.5、7h后,联合用药组患者心率、脉率乘积(RPP)均显著低于氨氯地平组(P均<0.01)。治疗后,与氨氯地平组比较,联合用药组患者的血压达标率(56.36%比87.27%)、心率达标率(38.18%比92.73%)、心率血压同时达标率(25.45%比81.82%)显著提高(P均<0.01)。结论:盐酸艾司洛尔联合苯磺酸氨氯地平片治疗高血压合并主动脉夹层患者,能够快速、安全、有效地控制血压和心率。Objective：To explore therapeutic effect of esmolol hydrochloride combined amlodipine on patients with hyper-tension complicated aortic dissection （AD） and its influence on patient＆#39;s blood pressure （BP） and heart rate （HR） .Methods：A total of 110 patients with hypertension complicated AD were randomly and equally divided into amlodipine group and combined treatment group （received amlodipine and esmolol） .Results：Compared with before treatment , after treatment 0. 5 ,1. 5 and 7h ,there were significant reductions in systolic blood pressure （SBP） and diastolic blood pressure （DBP） in both groups ,P〈0.01 ,on 7h after treatment ,SBP level of combined treatment group significantly reduced than that of amlodipine group [（101.5 ± 7.8） mmHg vs .（123.4 ± 10.2） mmHg ,P〈0.01];on 0.5 ,1.5 and 7h after treatment ,HR and rate pressure product （RPP） of combined treatment group significantly reduced than those of amlodipine group , P〈0. 01 all. Compared with amlodipine group after treatment , there were significant rise in standard-reaching rates of BP （56.36% vs .87.27% ） ,HR （38.18% vs .92.73% ） and BP＋HR （25.45% vs .81.82% ） in combined treatment group , P〈0.01 all. Conclusion：Esmolol combined amlodipine can control blood pressure and heart rate rapidly ,safely and effec-tively in patients with hypertension complicated aortic dissection .

关 键 词：高血压 主动脉疾病 氨氯地平 艾司洛尔 

分 类 号：R544.1[医药卫生—心血管疾病]