缬沙坦联合氨氯地平或氢氯噻嗪改善高血压患者血压变异性及生活质量  

Valsartan combined amlodipine or hydrochlorothiazide improving blood pressure variability and quality of life in aged patients with hypertension

作　　者：汪顺银[1] 张震洪[1] 梁俊杰[1] 许志文[1] 梁栋良 

机构地区：[1]广东省佛山市第二人民医院心血管内二科,广东佛山528000

出　　处：《心血管康复医学杂志》2015年第3期303-307,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:比较缬沙坦联合氨氯地平或氢氯噻嗪对老年高血压患者血压变异性及生活质量的影响。方法:纳入127例2、3级老年高血压患者,随机分为缬沙坦联合氨氯地平组(Val+Am组,64例)和缬沙坦联合氢氯噻嗪组(Val+Hyd组,63例),观察治疗前后各组血压昼夜节律及变异性、生活质量情况。结果:(1)两组治疗后24hSBP、DBP、SBPV、DBPV,白昼SBP、DBP、SBPV、DBPV,夜间、晨峰的SBP、DBP均明显下降(P<0.05或P<0.01);(2)与Val+Hyd组比较,Val+Am组24hSBP[(120.6±10.2)mmHg比(110.9±11.3)mmHg]、白昼SBP[(120.6±11.3)mmHg比(111.6±11.37)mmHg]、夜间SBP[(118.5±11.6)mmHg比(108.6±11.9)mmHg]、晨峰SBP[(26.2±13.7)mmHg比(23.0±10.4)mmHg]下降更显著(P<0.05或P<0.01);24hSBPV[(10.7±2.2)mmHg比(8.2±2.0)mmHg]、白昼SBPV[(10.4±1.9)mmHg比(8.1±2.1)mmHg]下降更显著(P均<0.01);生活质量的体力、精神健康,总体功能改善的百分比明显升高(P<0.05或<0.01)。结论:缬沙坦联合氨氯地平或氢氯噻嗪均能改善老年高血压患者血压变异性和生活质量,但缬沙坦联合氨氯地平效果更佳。Objective：To compare influence of valsartan （Val） combined amlodipine （Am） or hydrochlorothiazide （Hyd） on blood pressure variability and quality of life in aged patients with hypertension .Methods：A total of 127 aged patients with hypertension stage 2 and 3 were randomly divided into Val ＋ Am group （n=64） and Val ＋ Hyd group （n=63） .Circadian rhythm and variability of blood pressure and quality of life were observed in both groups before and after treatment .Results：（1） After treatment ,the 24hSBP ,DBP ,SBPV , DBPV and daytime SBP , DBP ,SBPV ,DBPV ,and nighttime ,morning surge of SBP and DBP all significantly reduced in both groups;（2） Compared with Val＋ Hyd group ,there were significant reductions in 24hSBP [（120.6 ± 10.2） mmHg vs . （110.9 ± 11.3） mmHg] ,daytime SBP [（120.6 ± 11.3） mmHg vs .（111.6 ± 11.37） mmHg] ,nighttime SBP [（118.5 ± 11.6） mmHg vs .（108.6 ± 11.9） mmHg] ,morning surge of SBP [ （26.2 ± 13.7） mmHg vs .（23.0 ± 10.4） mmHg] （P〈0.05 or 〈0.01）;24hSBPV [ （10.7 ± 2.2） mmHg vs .（8.2 ± 2.0） mmHg] ,daytime SBPV [ （10.4 ± 1.9） mmHg vs .（8.1 ± 2.1） mmHg] （P〈0.01 all）;significant rise in improved percentages of physical health ,mental health and total function in quality of life （P〈0.05 or 〈0.01） in Val ＋ Am group .Conclusion：Valsartan combined amlodipine or hydrochlorothiazide can both effectively improve blood pressure variability and quality of life in aged pa-tients with hypertension ,and the effect of the former is even better .

关 键 词：高血压 生活质量 氨氯地平 氢氯噻嗪 

分 类 号：R544.1[医药卫生—心血管疾病]