幽门螺杆菌毒力相关基因A及其亚型多样性与胃癌的关系  

Relationship between cytotoxin-associated gene A protein of H.pylori,its subtype diversity and gastric cancer

作　　者：刘鹿[1] 王林[2] 刘纯杰[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071 [2]军事医学科学院解放军第307医院,北京100071

出　　处：《解放军医学院学报》2015年第6期618-620,共3页Academic Journal of Chinese PLA Medical School

基　　金：国家级新药创制重大专项(2012ZX09301003-001-005)~~

摘　　要：胃癌作为最常见的消化道恶性肿瘤之一,幽门螺杆菌(Helicobacter pylori,H.pylori)感染与胃癌的发生有密切的关系,其中H.pylori毒力相关因子A(CagA)成为胃癌发病机制研究的热点。本文用新的视角总结了CagA参与的病理活动和其在胃癌发生、发展中可能起到的作用,同时对CagA及其亚型多样性与胃病程度的关系进行论述。Gastric cancer is one of the most common gastrointestinal malignancies and it has close relationship with the infection of H.pylori. The cytotoxin-associated gene A （CagA） of H.pylori has become a research hotspot for the study of the pathogenesis of gastric cancer. This study summarizes the pathological activities and its possible role in the occurrence of gastric cancer and discusses the relationship between CagA and gastric cancer.

关 键 词：幽门螺杆菌 毒力相关基因A 胃癌 

分 类 号：R377[医药卫生—病原生物学] R735.2[医药卫生—基础医学]