维甲酸相关孤儿受体在免疫系统的研究进展  

Research Advances of Retinoid-related Orphan Receptors in Immune System

作　　者：时静祥[1] 杜智[1] 

机构地区：[1]天津医科大学附属天津市第三中心医院肝胆外科天津市人工细胞重点实验室,天津300070

出　　处：《医学综述》2015年第11期1937-1939,共3页Medical Recapitulate

基　　金：天津市应用基础及前沿技术研究计划(11JCYBJC27700)

摘　　要：维甲酸相关孤儿受体属于类固醇激素受体超家族;在机体免疫系统的分化成熟中至关重要,其在次级淋巴组织发育、T淋巴细胞分化成熟及T细胞的谱系分化过程中均起重要作用。近年来,人们通过深入研究进一步阐明了该受体为配体依赖的转录因子;并揭示了其在一些疾病过程中的作用,包括自身免疫病及肿瘤。该文对其相关研究进行综述。Retinoid-related orphan receptors are transcription factors belonging to the steroid hormone receptor superfamily; they play critical roles in immune system,as revealed in several studies that they are essential for the development of lymphoid tissues,differentiation and maturation of T lymphocytes and T cell lineage specification.Recent reports confirmed the receptors are ligand dependent transcription factors and revealed their roles in some diseases,including several autoimmune diseases and tumors.Here is to make a review of the preceding aspects of the receptors.

关 键 词：维甲酸相关孤儿受体 类固醇激素受体 免疫 

分 类 号：R392.12[医药卫生—免疫学]