骨钙素在动脉粥样硬化形成中的作用研究进展  

Progress of Effect of Osteocalcin on Atherosclerotic Formation

作　　者：李琳琳[1] 冯淑芝[1] 

机构地区：[1]天津医科大学总医院保健医疗部天津市老年病研究所,天津300052

出　　处：《医学综述》2015年第11期1942-1945,共4页Medical Recapitulate

摘　　要：骨钙素是成骨细胞分泌的非胶原蛋白,大部分位于骨基质中,少量分泌入血循环。目前临床测量的血清骨钙素主要用来衡量骨转化和骨形成的速率。研究发现骨钙素对动脉粥样硬化形成的过程中也起着重要的作用,且骨钙素在血管壁和循环中对动脉粥样硬化的作用机制完全相反。该文对骨钙素在骨代谢,能量代谢作用的基础上予以综述,对循环中和钙化斑块处的骨钙素对动脉粥样硬化形成过程中所起的作用予以深入探讨。Osteocalcin is a none collagenous protein synthesized by osteoblasts.Most osteocalcin is deposited on the bone matrix,with a little being secreted in the blood.At present,osteocalcin is a useful marker of bone turnover and bone formation.Recently,studies have shown that osteocalcin plays an important role in process of atherosclerosis.However,osteocalcin on vessel wall and in serum have an opposite effect on atherosclerosis.Here is to make a review of the role of osteocalcin in bone and in energy metabolism ,as well the impact on the process of atherosclerosis determined by its location in serum or in calcified plaque .

关 键 词：骨钙素 骨祖细胞 内皮祖细胞 羟磷灰石 

分 类 号：R543.5[医药卫生—心血管疾病]