海洋无脊椎动物金属硫蛋白研究进展  

A review on the research of metallothionein in marine invertebrates

作　　者：吕新芳[1] 毛伟腾 滑朝阳 李玉春[1] 

机构地区：[1]山东大学威海分校海洋学院,山东威海264209

出　　处：《海洋通报》2015年第3期241-246,共6页Marine Science Bulletin

摘　　要：金属硫蛋白(metallothionein,MT)在海洋无脊椎动物中广泛存在,对多种重金属具高亲和性,在生物体内重金属解毒、必需金属离子调控和体内自由基清除等方面具有重要作用。综述了近几十年来海洋无脊椎动物金属硫蛋白的研究进展,着重介绍了软体动物(Mollusca)、节肢动物(Arthropoda)以及棘皮动物(Echinodermata)金属硫蛋白的研究现状,分析了无脊椎动物金属硫蛋白的特点,对海洋无脊椎动物金属硫蛋白的研究进行了总结。近年来,海洋无脊椎动物金属硫蛋白的研究热点主要集中在金属硫蛋白不同组织定位及蛋白序列多态性对其功能的影响、异构体在动物体内发挥的不同作用等。我国近海的重金属污染日益严峻,金属硫蛋白在重金属生物毒理效应等方面发挥重要作用,海洋无脊椎动物金属硫蛋白在生态毒理领域的研究日趋受到重视,对海洋无脊椎动物金属硫蛋白的研究亟待加强。Metallothionein （MT） widely exists in marine invertebrates, and it is important in the detoxification of heavy metals, the metabolism of intracellular zinc and copper, and the scavenging of reactive oxygen species. In this article, the studies of metallothionein in marine invertebrates including mollusca MT, arthropod MT and echinoderm MT were reviewed. In addition, the characteristics and research highlights of invertebrates MT were analyzed. MTs in variant tissues and different isoforms of MTs may accomplish different function. Researchers have revealed that MT polymorphism might be related with its phenotypes. It′s advised that studies on metallothionein of marine invertebrates are important and necessary for marine biodiversity conservation, heavy metal toxic effects, marine biological resource management, and the artificial raising of marine products. Based on this, the existing questions and research direction of metallotionein in the future were summarized finally.

关 键 词：金属硫蛋白 海洋无脊椎动物 重金属 

分 类 号：Q178.53[生物学—水生生物学]