高效液相色谱法快速分析手性联萘酚的教学实践  

Teaching practice for rapid analysis of chiral binaphthol by using high-performance liquid chromatography

作　　者：王秧年[1] 陆大东[1] 奚忠华[1] 叶涛[1] 章文伟[1] 李琳[1] 张剑荣[1] 

机构地区：[1]南京大学国家级化学实验教学示范中心,江苏南京210093

出　　处：《实验技术与管理》2015年第6期168-171,共4页Experimental Technology and Management

基　　金：国家基础科学人才培养基金(J1103310;1210030);2010年教育部"质量工程"化学实验课程优秀教学团队项目

摘　　要：手性联萘酚(BINOL)的合成、对映异构体拆分及其e.e.值测定是大学有机化学实验教学的重要内容。在教学过程中,引导学生自主建立运用高效液相色谱法(HPLC)快速分析手性BINOL合成产物的实验方法。这不仅有助于拓展学生的视野、提高他们的实验技能和科学素养,还能有效地践行以学生为主体的教学实践。Synthesis of ehiral binaphthol （BINOL）, resolution of its enantiomers, and determination of e. e. value are very important parts for experimental teaching of organic chemistry. During the experimental teaching, an experimental method for rapid analysis of chiral B]NOL products is built independently by students by means of high performance liquid chromatography （HPLC）. This not only helps them expand their horizons and improve their experimental skills as well as their scientific literacy, hut also effectively implements the teaching practice based on a student-centered learning.

关 键 词：联萘酚(BINOL) 手性 高效液相色谱法(HPLC) 快速分析 e.e.值 

分 类 号：G642.0[文化科学—高等教育学]