坎地沙坦治疗急性心肌梗死后心肌重塑的疗效观察  

Effect Observation of Candesartan on myocardial remodeling after acute myocardial infarction

作　　者：师振霞[1] 邵磊[2] 

机构地区：[1]河南工程学院校医院,郑州451191 [2]郑州大学第二附属医院,郑州450014

出　　处：《医药论坛杂志》2015年第5期15-16,19,共3页Journal of Medical Forum

基　　金：河南省科技厅基础与前沿技术研究计划项目(132300410418)

摘　　要：目的观察坎地沙坦对急性心肌梗死后心肌重塑-心室重塑的影响。方法选择2013年3月—2014年2月郑州大学第二附属医院住院的急性心肌梗死患者306例,随机分为缬沙坦治疗组和坎地沙治疗坦组,疗程20周。观察两组治疗前后左室舒张末期内径、左室射血分数、基质金属蛋白酶-9(MMP-9)、高敏C-反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)水平变化。结果治疗前后左室舒张末期内径、MMP-9、水平明显降低(P<0.05);左室射血分数明显提高(P<0.05)。结论坎地沙坦可以改善急性心肌梗死后的心肌重塑,并减少器官中MMP-9、hs-CRP、TNF-α水平。Objective To observe the effects of candesartan on myocardial remodeling after acute myocardial infarction. Methods Totally 306 cases of acute myocardial infarction patients selected from June 2010 to June 2013 in our hospital were randomly divided into valsartan treatment group and candesartan treatment group, treatment for 20 weeks, changes in left ventricular end diastolic diameter, left ventricular ejection fraction and blood MMP - 9, hs - CRP, TNF -α levels of the two groups were observed before and after treatment. Results Before and after the treatment, the left ventricular end diastolic diameter, blood MMP - 9, hs - CRP, TNF - α evels were significantly decreased （ P 〈 0. 05 ） , and left ventricular ejection fraction was significantly increased （P 〈 0. 05）. Conclusion Candesartan can reduce the myocardial remodeling after acute myocardial infarction, and can reduce the MMP - 9, hs - CRP, TNF -α expression levels.

关 键 词：心肌梗死 坎地沙坦 左室舒张末期内径 左室射血分数 

分 类 号：R542.2[医药卫生—心血管疾病]