缺氧缺血性脑病与孕母年龄和高迁移率蛋白-1关系  

Accociations of age of pregnant women and serum hmgb1 of newborn with neonatal hypoxic-ischemic encephalopathy

作　　者：郭庆辉[1] 杨慧军 刘皎婧 李朝霞[1] 王莉华[1] 王珊丹[1] 张雪[1] 

机构地区：[1]山东大学第二医院儿科,山东济南250033 [2]山东省妇幼保健院生殖医学科

出　　处：《中国公共卫生》2015年第6期833-835,共3页Chinese Journal of Public Health

摘　　要：目的探索缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)与母亲怀孕年龄及血清中高迁移率蛋白-1(high mobility group box protein 1,hmgb1)水平相关性,为有效预防和减少HIE的发生提供依据。方法随机选取山东大学第二医院于2012年3月—2014年3月收治的住院患者60例为病例组,同期60名正常新生儿为对照组。采用酶联免疫-双抗体夹心法测定病例组和对照组的血清hmgb1水平,并记录其孕母年龄,进行统计学分析。结果病例组母亲怀孕平均年龄较大,为(33.5±4.7)岁,高龄产妇的比例明显高于对照组;出生后2h内病例组各种程度HIE患儿(重、中、轻)的血清hmgb1水平均高于对照组,病情越严重,hmgb1在血清中的含量越高(174.88±9.12)ng/m L,且恢复正常的时间越长。结论 HIE与母亲怀孕年龄及血清中hmgb1水平相关,高龄产妇易导致HIE,hmgb1是早期临床检测HIE病情严重程度的指标之一。Objective To explore associations of the age of pregnant women and serum level of high mobility group box protein 1 （hmgbl）with the occurrence of neonatal hypoxic-ischemic encephalopathy（HIE） and to provide a basis for effective prevention of HIE. Methods With random sampling,60 hospitalized neonatal hypoxic-ischemic encephalopathy cases and 60 healthy newborns （controls） were selected in No. 2 Hospital of Shandong University from March 2012 through March 2014. Serum hmgbl levels of all the newborns were determined with enzyme-linked immunosorbent assay （ELISA）. Results The maternal age of the cases （33.5 ~ 4. 7 years） was significantly higher than that of the controls. Serum hmgbl two hours within the birth in the cases was significantly higher than that in the controls and positively cor- related with the severity of HIE and the recovery time from the disease. Conclusion Maternal age is positively correlated with neonatal HIE and hrngbl of the newborn is a early indicator for clinical severity of HIE.

关 键 词：新生儿缺氧缺血性脑病 怀孕年龄 高迁移率蛋白-1(hmgb1) 血清 

分 类 号：R722.1[医药卫生—儿科]