2006-2013年四川省蒲江县古佛村人群血吸虫抗体消长监测  

Surveillance on Trend of Schistosomiasis Antibody Levels in Gufo Village of Pujiang County,Sichuan Province,2006-2013

作　　者：徐惠蓉[1] 伍建军[1] 侯明[1] 张辉[1] 何建川[1] 吴子松[2] 

机构地区：[1]蒲江县疾病预防控制中心,四川蒲江611630 [2]四川省疾病预防控制中心寄生虫病研究所

出　　处：《寄生虫病与感染性疾病》2015年第2期83-86,共4页Parasitoses and Infectious Diseases

摘　　要：目的了解山丘型血吸虫病轻疫区人群血吸虫病抗体水平的变化规律,为评价免疫诊断方法提供参考。方法选择四川省蒲江县古佛村,每年秋季用间接血凝试验(IHA)检查村民,血阳者再作Kato-Katz法检查。筛选出2006-2013年连续参加检查的人群,检查分析人群血吸虫抗体阳性率、抗体滴度、每克粪便虫卵数(EPG)等的变化情况。结果 2006-2013年有263人连续参加了血吸虫病检查,人群抗体阳性率从4.19%下降到1.83%,人群抗体滴度(GMRT)从1.29下降到1.07。抗体阳性者转归以阴转为主,滴度逐年降低;阴性者维持阴性为主。总血清阳性率与总感染率呈正相关(r=0.33,P<0.05)。结论四川省蒲江县古佛村山丘型血吸虫病轻疫区人群血吸虫抗体阳性率维持在较高水平,应开发适用于不同流行程度疫区的血吸虫病免疫诊断试剂。Objective To explore the change tendency of schistosomiasis antibodies in population in mountainous with low schistosomiasis endemic so as to provide reference for immunodiagnosis. Methods Gufo villagers were conducted heamagglutination assay （IHA） for schistosomiasis screening and those of positive was examined by Kato - Katz technique from 2006 to 2013. The positive rate of antibody of schistosomiasis and number of eggs per gram of feces were detected. Results A total of 263 people were investigated from 2006 to 2013. The posi- tive rate for schistosomiasis antibodies decreased from 4. 19% to 1.83% , and the geometric mean reciprocal titer （GMRT） decreased from 1.29 to 1.07. The antibodies tended to be negative in most antibody - positive people and the GMRT decreased gradually. The antibodies remained negative population was most antibody - negative people. Total serum positive rate was correlated to the total infection rate （ r = 0. 33, P 〈 0.05 ） . Conclusion The positive rate of schistosomiasis antibodies in population of mountainous with low schistosomia- sis endemic has maintained at a relatively high level. Therefore, diagnostic reagents should be developed in consideration of the region endemic .

关 键 词：血吸虫 抗体 滴度 

分 类 号：R532.21[医药卫生—内科学]