预先短暂性脑缺血发作时间、次数等对后继脑梗死神经保护的研究  

The study on neuroprotective effect of time and number of previous transient ischemic attack on cerebral infarction

作　　者：常四鹏 牛敬忠[2] 

机构地区：[1]泰山医学院,在读研究生泰山271016 [2]泰山医学院附属医院神经内科,泰山271000

出　　处：《中国实用神经疾病杂志》2015年第10期30-31,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的：探究预先短暂性缺血发作时间、发作次数与脑梗死发作间隔对后继脑梗死患者神经的保护作用，为临床治疗提供指导。方法回顾性选取自2010‐02来我院就诊的脑梗死患者213例为研究对象，其中不存在预先T IA患者131例（61.50％）为脑梗死A组，预先发生T IA患者82例（38.50％）为脑梗死B组，采用日常生活活动能力（ADL ）评分标准，从预先短暂性脑缺血发作时间、发作次数与脑梗死发作时间间隔三个方面分析2组患者在神经功能恢复方面的情况。结果脑梗死A组Ⅰ级预后79例（60.31％），脑梗死B组Ⅰ级预后56例（68.29％），2组差异无统计学意义（ P＞0.05），但脑梗死B组预先短暂性脑缺血发作次数在2～3次、发作时间＜10 min与脑梗死间隔≤1周时与脑梗死A组差异有统计学意义（ P＜0.05）。结论脑梗死前预先短暂性脑缺血发作可能会产生神经保护作用，其神经保护作用与短暂性缺血发作持续时间、发作次数及与脑梗死时间间隔具有一定关系。Objective To explore neuroprotective effect of time and number of previous transient ischemic attack on cere‐bral infarction ,providing guidance for clinical treatment.Methods We retrospectively selected 213 patients with cerebral in‐farction from 2010 February in our hospital as research objects ,among which 131 patients with non‐previous TIA were consid‐ered as group A（61.50% ） ,while 82 cases with previous TIA as group B （38.50% ）. The frequency of TIA as well as onset time of cerebral infarction were assessed by activities of daily living （ADL） between two groups to analyze the nerve functional recovery.Results 79 cases （60.31% ） in group A reached grade I in prognosis ,and 56 cases （68.29% ） in B group ,and the difference had no statistical significance （χ2 =1.386 ,P〉0.05）. Episode in 2‐3 times ,duration less than 10 minutes and inter‐val with one week or less in group B had significant difference compared with group A （P〈0.05）.Conclusion Previous transi‐ent ischemic attack on cerebral infarction may have neuroprotective effect ,which could be related to frequency ,duration and in‐terval.

关 键 词：短暂脑缺血发作 脑梗死 缺血耐受 

分 类 号：R743.33[医药卫生—神经病学与精神病学]