维生素D信号通路在骨骼稳态维持中的作用  

New insights of vitamin D signaling in the maintains of bonehomeostasis

作　　者：黄启钊[1] 戚华兵[1] 杜晓兰[1] 陈林[1,2] 

机构地区：[1]第三军医大学大坪医院野战外科研究所创伤实验室骨代谢修复中心创伤、烧伤与复合伤国家重点实验室,重庆400042 [2]第三军医大学大坪医院康复理疗科,重庆400042

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2015年第2期156-163,共8页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：科技部重大研究计划项目(2014CB942904);国家自然基金重点项目(81030036);国家自然基金面上项目(31271562)

摘　　要：维生素D作为一种重要的类固醇激素在骨骼发育和稳态维持中发挥重要作用。机体从外界获取的维生素D需在体内经过2次羟化转变为活性1,25-二羟基维生素D3,然后与维生素D受体(vitamin D receptor,VDR)结合后发挥生物学作用。传统观点认为1,25-二羟基维生素D3在体内主要通过内分泌途径作用于肠道和肾脏,通过调节钙磷吸收和重吸收维持矿物质稳态,并因此间接调节骨骼稳态。近年发现1,25-二羟基维生素D3能直接作用于成骨细胞、破骨细胞和软骨细胞等,通过调节其增殖、分化直接调节骨形成与骨吸收,维持骨稳态的平衡。The important steroid hormone, vitamin D, plays an important role in the process of bone develop- ment and homeostasis. Exogenous vitamin D requires two metabolic conversions, 25-hydroxylation in the liver and 1α-hy- droxylation in the kidney, to become its active form, 1, 25-dihydroxyvitamin D, which binds to vitamin D receptor to modulate bone and mineral homeostasis. The generally accepted view is that vitamin D predominately acts on intestine and kidney to modulate calcium and phosphate homeostasis through an endocrine pathway, which indirectly regulates bone ho- meostasis. Recent years, with the advancement of tissue-specific intervention of VDR signaling pathway, scientists find a new pattern of vitamin D action which is independent of mineral metabolism. In their view, vitamin D exerts its effects mainly on the proliferation and differentiation of bone cells and then regulate bone homeostasis directly.

关 键 词：维生素D 1 25-二羟基维生素D3 骨稳态 

分 类 号：R681[医药卫生—骨科学]