不同钙剂对男性多次双份机采献血者影响的研究  

The study of two kinds of oral calcium supplementation on male regular double plateletpheresis donors

作　　者：熊恺轩[1] 孙革[1] 卢亮[1] 张艳艳[1] 夏祝天 伍娟[1] 李金玉[1] 庄乃保[1] 

机构地区：[1]深圳市血液中心,广东深圳518035

出　　处：《中国输血杂志》2015年第5期540-542,共3页Chinese Journal of Blood Transfusion

基　　金：深圳市卫生计生系统科研项目(201402092)

摘　　要：目的研究口服碳酸钙和葡萄糖酸钙对男性多次机采献血者双份机采中血清钙、磷和甲状旁腺素(PTH)的影响。方法随机抽取男性多次机采献血者77例,随机的分为3组:未补钙组,葡萄糖酸钙组(采前20 min口服葡萄糖酸钙4支,元素钙360 mg),碳酸钙组(采前20 min口服碳酸钙2片,元素钙1 200 mg),检测献血者机采前-20 min)、机采开始(0 min)、机采中(40 min)、后(80 min)血清钙、磷和PTH含量,观察献血者的柠檬酸盐抗凝剂相关反应。结果双份机采后,3个组的钙分别为(2.13±0.06),(2.23±0.07),(2.23±0.07)mmol/L;3个组双份机采后的PTH分别为(153±57),(121±35),(104±40)pg/L;机采中和机采后3组的钙、PTH比较,均为P<0.01;采集后碳酸钙组与葡萄糖酸钙组比较,血清钙和PTH比较,葡萄糖酸钙、碳酸钙组与未补钙组比较,轻度抗凝剂反应的发生率均为P<0.05。结论口服碳酸钙和葡萄糖酸钙能有效稳定机采中血清钙,PTH的波动,献机采前20 min口服碳酸钙是值得推荐的。Objective To evaluate the effect of oral calcium gluconate and calcium carbonate on male regular double plateletpheresis donors. Methods A total of 77 male regular double plateletpheresis donors were divided randomly into three groups： no calcium group,calcium gluconate group（ supplemented with oral calcium gluconate 20 minutes before plateletpheresis,calcium 360mg） and calcium carbonate group（ supplemented with oral calcium carbonate 20 minutes before plateletpheresis,calcium 1200mg）. Serum calcium,serum phosphate,PTH were measured before（- 20 min）,in the beginning of（ 0 min）,in the middle of（ 40 minutes） and at the end of（ 80 minutes） double plateletpheresis. During the observation period,citrate toxicity symptoms were recorded. Results At the end of double plateletpheresis,the concentrations of serum calcium and PTH in the three groups were（ 2. 13 ± 0. 06）,（ 2. 23 ± 0. 07）,（ 2. 23 ± 0. 07） mmol / L and（ 153 ± 57）,（ 121± 35）,（ 104 ± 40） pg / L,respectively. In the middle of and at the end of double plateletpheresis,serum calcium and parathyroid hormone were significantly different among three groups（ P〈 0. 01）. At the end of double plateletpheresis,serum calcium and parathyroid hormone showed significant difference between calcium carbonate group and calcium gluconate group,（ P〈0. 05）. The addition of calcium gluconate or calcium carbonate significantly reduced the frequency of citrate-related symptoms（ P 〈0. 05）. Conclusion The addition of calcium gluconate or calcium carbonate seems to have beneficial effect in stabilizing serum calcium,serum phosphate and PTH during plateletpheresis. Supplementation of oral calcium carbonate 20 minutes before double plateletpheresis is recommended.

关 键 词：葡萄糖酸钙 双份机采 血清钙 甲状旁腺素 碳酸钙 

分 类 号：R193.3[医药卫生—卫生事业管理]