Electro-oxidation of paracetamol in the presence of malononitrile:Application for green,efficient,none-catalyst,simple and one-pot electro-synthesis of new paracetamols  

作　　者：Alireza Asghari Mohsen Ameri Ali Akbar Ziarati Sepideh Radmannia Ali Amoozadeh Behruz Barfi Leila Boutorabi 

机构地区：[1]Department of Chemistry,Semnan University

出　　处：《Chinese Chemical Letters》2015年第6期681-684,共4页中国化学快报（英文版）

基　　金：Semnan University Research Council for financial supports of this work

摘　　要：Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution （0.15 tool/L, pH 7）, using cyclic voltammetric techniques. The results indicated that the N-acetyl-p-benzoquinone-imine derived from paracetamol participates in a 1,4-Michael-ts, pe addition reaction with the malononitrile to form the corresponding paracetamol derivatives （6a, 7a）. The present study has led to the development of a simple, green, non-catalyst and one-pot electrochemical method with high atom economy under mild conditions.Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution （0.15 tool/L, pH 7）, using cyclic voltammetric techniques. The results indicated that the N-acetyl-p-benzoquinone-imine derived from paracetamol participates in a 1,4-Michael-ts, pe addition reaction with the malononitrile to form the corresponding paracetamol derivatives （6a, 7a）. The present study has led to the development of a simple, green, non-catalyst and one-pot electrochemical method with high atom economy under mild conditions.

关 键 词：Electro-oxidation Cyclic voltammetry Malononitrile Michael addition type Paracetamol 

分 类 号：TQ463[化学工程—制药化工]