婴儿肺炎鼻咽分泌物病毒病原学分析  

Analysis of viral etiology for nasopharyngeal secretions in neonatal pneumonia

作　　者：王敏[1] 王林霞[1] 汤鲁明[2] 严纯雪[1] 潘国权[1] 

机构地区：[1]温州医科大学附属第二医院儿童ICU,浙江省温州325027 [2]温州医科大学附属第二医院急诊科,浙江省温州325027

出　　处：《中国基层医药》2015年第12期1782-1784,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医药卫生科技计划项目（2013RCA039）

摘　　要：目的：探讨不同月龄段和不同季节婴儿肺炎病毒病原学谱。方法对1073例婴儿肺炎的临床资料进行回顾性分析，对患儿鼻咽分泌物行直接免疫荧光法检测，对检测结果进行统计分析。结果1073例肺炎患儿中，病毒检出阳性406例，阳性率为37．8％，其中混合感染7例。呼吸道合胞病毒（RSV）检出率最高，共检出334例，占82．3％；1～6个月龄小婴儿 RSV 感染率为36．4％，与＞6～12个月龄大婴儿 RSV 感染率的26．5％比较，差异有统计学意义（χ2＝12．25，P ＜0．05）；冬春季 RSV 感染率为39．7％，显著高于夏秋季的13．6％；冬春季副流感病毒3感染率为1．8％，显著低于夏秋季的9．1％，差异有统计学意义（χ2＝31．27， P ＜0．05）。结论婴儿肺炎病毒病原学最常见的为 RSV，对于小婴儿和冬春季要注意 RSV 感染，夏秋季要注意副流感病毒3感染。Objective To explore the viral etiology spectrum of different age and different seasons for neo-natal pneumonia.Methods Medical records of 1 073 cases of neonatal pneumonia in our hospital were retrospectively analyzed,line direct immunofluorescence assay were used to detect nasopharyngeal secretions of newborns,the test results were statistically analyzed.Results In 1 073 cases with neonatal pneumonia,406 cases were detected positive with virus infected,the positive rate was 37.8%,7 cases were mix infected.334 cases were infected by respiratory syncytial virus（RSV）,which had the highest detection rate,accounting for 82.3%;RSV infection rate in 1 -6 month baby was 36.4%,which was higher than the 〉6 -12 month -old baby with RSV infection rate 26.5%,the difference was statistically significant（χ2 =12.25,P 〈0.05）;RSV infection rate in winter and spring group was 39.7%,which was significantly higher than that in autumn and winter group（13.6%）;PIV3 infection rate in winter and spring group was 1.8%,significantly lower than that in autumn and summer group（9.1%）,the difference was statistically signifi-cant（χ2 =31.27,P 〈0.05 ）.Conclusion RSV is the most common viral in neonatal pneumonia,more attention should be payed to RSV infection control in small babies and at winter and spring,pay attention to PIV3 infection at autumn and summer.

关 键 词：病毒学 鼻咽分泌物 肺炎 婴儿 

分 类 号：R722.135[医药卫生—儿科]