六味地黄丸加味治疗肝肾阴虚证绝经后骨质疏松症临床研究  

Clinical study on addition treatment of liver -kidney yin deficiency and postmenopausal osteoporosis with Liuwei Dihuang pill

作　　者：张允[1] 曾喻[2] 廖敏[1] 姜迎[1] 罗勇[1] 刘青松[1] 陈世寅[1] 

机构地区：[1]四川省人民医院中医骨科,四川省成都610072 [2]四川省人民医院高压氧科,四川省成都610072

出　　处：《中国基层医药》2015年第12期1797-1801,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察六味地黄丸加味治疗肝肾阴虚证绝经后骨质疏松症的临床疗效。方法选择中医辨证为肝肾阴虚证的绝经后骨质疏松症患者120例，按随机数字表法分为 A、B、C 三组。A 组：给予六味地黄丸加味药物制成的蜜丸，每天2粒，连续服用6个月；B 组：给予唑来膦酸注射液5 mg 静脉滴注；C 组：同时给予中药蜜丸和唑来膦酸治疗；三组均同时服用碳酸钙 D3片；三组病例均观察、随访12个月，比较三组临床疗效。结果A、C 组治疗后3个月雌二醇水平与治疗前比较，差异有统计学意义（t ＝2．54，P ＝0．05，t ＝2．07， P ＝0．06）。A 组治疗后3个月、6个月 VAS 评分分别为（3．75±1．32）分、（2．06±1．53）分，与治疗前差异均有统计学意义（t ＝10．18，P ＝0．00，t ＝9．26，P ＝0．00）。A 组治疗后3个月、6个月 SF-36评分分别为（90．82±12．38）分、（105．82±9．06）分，与治疗前比较，差异均有统计学意义（t ＝8．40，P ＝0．00，t ＝5．21，P ＝0．00）。A 组治疗后6个月腰1～4骨密度为（0．85±0．07）g／m^2，与治疗前[（0．76±0．07）g／m^2]比较，差异有统计学意义（t ＝7．56，P ＝0．00）；A 组治疗后6个月 Wards 区骨密度与治疗前比较，差异有统计学意义（t ＝8．07，P ＝0．00）。C 组治疗后6个月腰1～4骨密度为（0．91±0．07）g／m^2，与 B 组[（0．88±0．05）g／m^2]比较，差异有统计学意义（t ＝27．19，P ＝0．00）；C 组治疗后6个月 Wards 区骨密度为（0．62±0．04）g／m^2，与 B 组比较，差异有统计学意义（t ＝26．22，P ＝0．00）。A 组治疗后6个月中医证候积分为（5．42±2．13）分，与 B 组[（10．75±4．08）分]比较，差异有统计学意义（t ＝13．29，P ＝0．00）。结论六味地黄丸加味能提高骨密度，减轻绝经后骨质疏松症患者骨痛，改善其生活质量，且无明显不�Objective To study the clinical effects of addition treatment of liver-kidney yin deficiency and postmenopausal osteoporosis with Liuwei Dihuang pill.Methods 120 patients suffering from postmenopausal osteopo-rosis who were determined to be subject to liver -kidney Yin deficiency by doctors of traditional Chinese medicine when they received treatment at the outpatient clinic of traditional Chinese medicine department of our hospital in the period from February 2010 to june 2013 were divided into three groups：group A,B and C,with the random number table.For group A：provided the honeyed pills made up by supplemented six -ingredient rehmannia pill,and taken two pills per day continuously for six months;For group B：provided 5mg of zoledronic acid injection for intravenous drip infusion;For group C：provided traditional Chinese medicine honeyed pills and zoledronic acid for treatment at the same time;all of the three groups take Calcium carbonate D3 at the same time;The three groups of cases until the 12th month were observed and followed -up.The clinical efficacy of three groups were compared.Results A,C group 3 months after treatment with estradiol levels compared with before treatment,the difference was statistically significant （t =2.54,P =0.05,t =2.07,P =0.06）.A group 3 months after treatment,the VAS scores at 6 months respectively （3.75 ±1.32）,（2.06 ±1.53）points before treatment,and the differences were statistically significant（t =10.18, P =0.00,t =9.26,P =0.00）.A group 3 months after treatment,the SF -36 scores at 6 months were （90.82 ± 12.38）,（105.82 ±9.06）% respectively,compared with that before treatment,the differences were statistically significant（t =8.40,P =0.00,t =5.21,P =0.00）.A group 6 months after treatment of lumbar 1 -4 bone density-were （0.85 ±0.07）g/m^2 ,and before treatment[（0.76 ±0.07）g/m^2 ]comparison,the difference was statistically significant（t =7.56,P =0.00）;A group 6 months after treatment of Wards bone density compared with before tre

关 键 词：骨质疏松 阴虚 骨密度 六味地黄丸 

分 类 号：R681[医药卫生—骨科学]